PUBLICATION

Reelin Signaling Controls the Preference for Social Novelty in Zebrafish

Authors
Vecchia, E.D., Donato, V.D., Young, A.M.J., Bene, F.D., Norton, W.H.J.
ID
ZDB-PUB-191015-11
Date
2019
Source
Frontiers in behavioral neuroscience   13: 214 (Journal)
Registered Authors
Keywords
5-HT, Reelin, autism, behavior, neurochemistry, neuroscience, social behavior, zebrafish
MeSH Terms
none
PubMed
31607872 Full text @ Front. Behav. Neurosci.
Abstract
Reelin (Reln) is an extracellular glycoprotein that is important for brain patterning. During development Reln coordinates the radial migration of postmitotic cortical neurons, cerebellar and hippocampal neurons, whereas it promotes dendrite maturation, synaptogenesis, synaptic transmission, plasticity and neurotransmitter release in the postnatal and adult brain. Genetic studies of human patients have demonstrated association between the RELN locus and autism spectrum disorder, schizophrenia, bipolar disorder, and Alzheimer's disease. In this study we have characterized the behavioral phenotype of reelin (reln) mutant zebrafish, as well as two canonical signaling pathway targets DAB adaptor protein 1a (dab1a) and the very low density lipoprotein receptor (vldlr). Zebrafish reln-/- mutants display a selective reduction in preference for social novelty that is not observed in dab1a-/- or vldlr-/- mutant lines. They also exhibit an increase in 5-HT signaling in the hindbrain that parallels but does not underpin the alteration in social preference. These results suggest that zebrafish reln-/- mutants can be used to model some aspects of human diseases in which changes to Reln signaling alter social behavior.
Genes / Markers
Figures
Figure Gallery (8 images)
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Expression
No data available
Phenotype
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
ic3030
    Insertion
    ic3031
      Small Deletion
      ic3032
        Indel
        1 - 3 of 3
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        Human Disease / Model
        Human Disease Fish Conditions Evidence
        autism spectrum disorderTAS
        1 - 1 of 1
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        Sequence Targeting Reagents
        No data available
        Fish
        Antibodies
        Name Type Antigen Genes Isotypes Host Organism
        Ab1-relnmonoclonalIgG1Mouse
        1 - 1 of 1
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        Orthology
        No data available
        Engineered Foreign Genes
        No data available
        Mapping
        No data available