PUBLICATION

TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in Zebrafish

Authors
Fillatre, J., Fauny, J.D., Fels, J.A., Li, C., Goll, M., Thisse, C., Thisse, B.
ID
ZDB-PUB-190913-12
Date
2019
Source
eLIFE   8: (Journal)
Registered Authors
Fauny, Jean-Daniel, Goll, Mary, Thisse, Bernard, Thisse, Christine
Keywords
developmental biology, zebrafish
Datasets
GEO:GSE119623
MeSH Terms
  • Gene Expression Regulation, Developmental*
  • Body Patterning*
  • Transcription Factors/metabolism*
  • Signal Transduction*
  • Animals
  • Zebrafish/anatomy & histology*
  • Zebrafish/embryology*
(all 7)
PubMed
31513014 Full text @ Elife
Abstract
In many vertebrates, establishment of Left-Right (LR) asymmetry results from the activity of a ciliated organ functioning as the LR Organizer (LRO). While regulation of the formation of this structure by major signaling pathways has been described, the transcriptional control of LRO formation is poorly understood. Using the zebrafish model, we show that the transcription factors and cofactors mediating or regulating the transcriptional outcome of the Hippo signaling pathway play a pivotal role in controlling the expression of genes essential to the formation of the LRO including ligands and receptors of signaling pathways involved in this process and most genes required for motile ciliogenesis. Moreover, the transcription cofactor, Vgll4l regulates epigenetic programming in LRO progenitors by controlling the expression of writers and readers of DNA methylation marks. Altogether, our study uncovers a novel and essential role for the transcriptional effectors and regulators of the Hippo pathway in establishing LR asymmetry.
Genes / Markers
Figures
Figure Gallery (11 images) / 2
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Expression
Phenotype
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
mk24
    Small Deletion
    mk23
      Indel
      mk26
        Indel
        pt19TgTransgenic Insertion
          s870TgTransgenic Insertion
            sa14593
              Point Mutation
              va1
                Small Deletion
                va2
                  Indel
                  va3
                    Small Deletion
                    va4
                      Small Deletion
                      1 - 10 of 10
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                      Human Disease / Model
                      No data available
                      Sequence Targeting Reagents
                      Fish
                      Antibodies
                      Orthology
                      No data available
                      Engineered Foreign Genes
                      Marker Marker Type Name
                      GFPEFGGFP
                      1 - 1 of 1
                      Show
                      Mapping
                      No data available