PUBLICATION
Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish
- Authors
- Xie, M., Kamenev, D., Kaucka, M., Kastriti, M.E., Zhou, B., Artemov, A.V., Storer, M., Fried, K., Adameyko, I., Dyachuk, V., Chagin, A.S.
- ID
- ZDB-PUB-190711-4
- Date
- 2019
- Source
- Proceedings of the National Academy of Sciences of the United States of America 116(30): 15068-15073 (Journal)
- Registered Authors
- Keywords
- Schwann cell precursors, bone, cartilage, glia, mesenchymal cells
- MeSH Terms
-
- Cell Differentiation
- Schwann Cells/cytology*
- Schwann Cells/metabolism
- Zebrafish/embryology
- Zebrafish/genetics
- Zebrafish/metabolism
- Osteocytes/cytology
- Osteocytes/metabolism
- Mice
- Embryo, Nonmammalian
- Nerve Fibers/metabolism
- Gene Expression
- Animals
- Nerve Tissue/cytology*
- Nerve Tissue/embryology
- Nerve Tissue/metabolism
- Neural Stem Cells/cytology
- Neural Stem Cells/metabolism
- Embryonic Development
- Chondrocytes/cytology*
- Chondrocytes/metabolism
- Neuroglia/cytology
- Neuroglia/metabolism
- Chromaffin Cells/cytology
- Chromaffin Cells/metabolism
- Neural Crest/cytology
- Neural Crest/growth & development
- Neural Crest/metabolism
- Neurons/cytology
- Neurons/metabolism
- Mesenchymal Stem Cells/cytology*
- Mesenchymal Stem Cells/metabolism
- Bone and Bones/cytology*
- Bone and Bones/embryology
- Bone and Bones/metabolism
- Melanocytes/cytology
- Melanocytes/metabolism
- Myelin Proteolipid Protein/genetics
- Myelin Proteolipid Protein/metabolism
- Multipotent Stem Cells/cytology
- Multipotent Stem Cells/metabolism
- Embryo, Mammalian
- SOXE Transcription Factors/genetics
- SOXE Transcription Factors/metabolism
- Biomarkers/metabolism
- Cell Lineage/genetics*
- PubMed
- 31285319 Full text @ Proc. Natl. Acad. Sci. USA
Citation
Xie, M., Kamenev, D., Kaucka, M., Kastriti, M.E., Zhou, B., Artemov, A.V., Storer, M., Fried, K., Adameyko, I., Dyachuk, V., Chagin, A.S. (2019) Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 116(30):15068-15073.
Abstract
Immature multipotent embryonic peripheral glial cells, the Schwann cell precursors (SCPs), differentiate into melanocytes, parasympathetic neurons, chromaffin cells, and dental mesenchymal populations. Here, genetic lineage tracing revealed that, during murine embryonic development, some SCPs detach from nerve fibers to become mesenchymal cells, which differentiate further into chondrocytes and mature osteocytes. This occurred only during embryonic development, producing numerous craniofacial and trunk skeletal elements, without contributing to development of the appendicular skeleton. Formation of chondrocytes from SCPs also occurred in zebrafish, indicating evolutionary conservation. Our findings reveal multipotency of SCPs, providing a developmental link between the nervous system and skeleton.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping