PUBLICATION

In Vitro and In Vivo Neuroprotective Effects of Stellettin B Through Anti-Apoptosis and the Nrf2/HO-1 Pathway

Authors
Feng, C.W., Chen, N.F., Wen, Z.H., Yang, W.Y., Kuo, H.M., Sung, P.J., Su, J.H., Cheng, S.Y., Chen, W.F.
ID
ZDB-PUB-190601-12
Date
2019
Source
Marine drugs   17(6): (Journal)
Registered Authors
Keywords
HO-1, Nrf2, Parkinson’s disease, apoptosis, oxidative stress, sponge-derived compound
MeSH Terms
  • Humans
  • Animals
  • Locomotion/drug effects
  • Aquatic Organisms/chemistry
  • Apoptosis/drug effects*
  • Parkinson Disease/drug therapy
  • Porifera/chemistry*
  • Oxidopamine/toxicity
  • Neuroprotective Agents/pharmacology
  • Heme Oxygenase-1/metabolism*
  • NF-E2-Related Factor 2/metabolism*
  • Triterpenes/chemistry
  • Triterpenes/isolation & purification
  • Triterpenes/pharmacology*
  • Disease Models, Animal
  • Cell Line
  • Zebrafish
  • Oxidative Stress/drug effects*
  • Cell Survival/drug effects
(all 19)
PubMed
31146323 Full text @ Mar. Drugs
Abstract
Pharmaceutical agents for halting the progression of Parkinson's disease (PD) are lacking. The current available medications only relieve clinical symptoms and may cause severe side effects. Therefore, there is an urgent need for novel drug candidates for PD. In this study, we demonstrated the neuroprotective activity of stellettin B (SB), a compound isolated from marine sponges. We showed that SB could significantly protect SH-SY5Y cells against 6-OHDA-induced cellular damage by inhibiting cell apoptosis and oxidative stress through PI3K/Akt, MAPK, caspase cascade modulation and Nrf2/HO-1 cascade modulation, respectively. In addition, an in vivo study showed that SB reversed 6-OHDA-induced a locomotor deficit in a zebrafish model of PD. The potential for developing SB as a candidate drug for PD treatment is discussed.
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Name Type Antigen Genes Isotypes Host Organism
Ab1-actbmonoclonal
    IgG1Mouse
    Ab3-thmonoclonalIgG1Mouse
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