PUBLICATION

Fish Scales Dictate the Pattern of Adult Skin Innervation and Vascularization

Authors
Rasmussen, J.P., Vo, N.T., Sagasti, A.
ID
ZDB-PUB-180724-2
Date
2018
Source
Developmental Cell   46(3): 344-359.e4 (Journal)
Registered Authors
Sagasti, Alvaro
Keywords
axon, dorsal root ganglia, metamorphosis, osteoblast, regeneration, scale, sensory nerve, skin, vasculature, zebrafish
MeSH Terms
  • Axons/metabolism*
  • Axons/ultrastructure
  • Vascular Remodeling/physiology
  • Epidermis/embryology*
  • Hair/embryology
  • Animals
  • Zebrafish/growth & development
  • Skin/blood supply*
  • Skin/innervation*
  • Skin/ultrastructure
(all 10)
PubMed
30032992 Full text @ Dev. Cell
Abstract
As animals mature from embryonic to adult stages, the skin grows and acquires specialized appendages, like hairs, feathers, and scales. How cutaneous blood vessels and sensory axons adapt to these dramatic changes is poorly understood. By characterizing skin maturation in zebrafish, we discovered that sensory axons are delivered to the adult epidermis in organized nerves patterned by features in bony scales. These nerves associate with blood vessels and osteoblasts above scales. Osteoblasts create paths in scales that independently guide nerves and blood vessels during both development and regeneration. By preventing scale regeneration and examining mutants lacking scales, we found that scales recruit, organize, and polarize axons and blood vessels to evenly distribute them in the skin. These studies uncover mechanisms for achieving comprehensive innervation and vascularization of the adult skin and suggest that scales coordinate a metamorphosis-like transformation of the skin with sensory axon and vascular remodeling.
Genes / Markers
Figures
Figure Gallery (14 images) / 2
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Expression
Phenotype
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
a129TgTransgenic Insertion
    cz1701TgTransgenic Insertion
      dt1261
        Point Mutation
        hu5333TgTransgenic Insertion
          j4blue
            Small Deletion
            la207TgTransgenic Insertion
              la211TgTransgenic Insertion
                mil1TgTransgenic Insertion
                  nim5TgTransgenic Insertion
                    pd46TgTransgenic Insertion
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                      Human Disease / Model
                      No data available
                      Sequence Targeting Reagents
                      No data available
                      Fish
                      Antibodies
                      Orthology
                      No data available
                      Engineered Foreign Genes
                      Marker Marker Type Name
                      BFPEFGBFP
                      CreEFGCre
                      DsRedEFGDsRed
                      EGFPEFGEGFP
                      GAL4EFGGAL4
                      GFPEFGGFP
                      KALTA4EFGKALTA4
                      mCherryEFGmCherry
                      RFPEFGRFP
                      TagRFPEFGTagRFP
                      1 - 10 of 10
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                      Mapping
                      No data available