PUBLICATION

Motile-Cilia-Mediated Flow Improves Sensitivity and Temporal Resolution of Olfactory Computations

Authors
Reiten, I., Uslu, F.E., Fore, S., Pelgrims, R., Ringers, C., Diaz Verdugo, C., Hoffman, M., Lal, P., Kawakami, K., Pekkan, K., Yaksi, E., Jurisch-Yaksi, N.
ID
ZDB-PUB-170104-8
Date
2017
Source
Current biology : CB   27(2): 166-174 (Journal)
Registered Authors
Fore, Stephanie, Kawakami, Koichi, Lal, Pradeep, Yaksi, Emre
Keywords
cilia, flow fields, fluid dynamics, motile cilia, multiciliated cells, olfactory coding, olfactory system, salmon, zebrafish
MeSH Terms
  • Odorants
  • Biophysical Phenomena
  • Epithelium/physiology*
  • Animals
  • Zebrafish Proteins/metabolism
  • Cilia/physiology*
  • Nose/physiology*
  • Smell*
  • Signal Transduction
  • Olfactory Receptor Neurons/cytology
  • Olfactory Receptor Neurons/metabolism
  • Zebrafish/physiology*
(all 12)
PubMed
28041793 Full text @ Curr. Biol.
Abstract
Motile cilia are actively beating hair-like structures that cover the surface of multiple epithelia. The flow that ciliary beating generates is utilized for diverse functions and depends on the spatial location and biophysical properties of cilia. Here we show that the motile cilia in the nose of aquatic vertebrates are spatially organized and stably beat with an asymmetric pattern, resulting in a robust and stereotypical flow around the nose. Our results demonstrate that these flow fields attract odors to the nose pit and facilitate detection of odors by the olfactory system in stagnant environments. Moreover, we show that ciliary beating quickly exchanges the content of the nose, thereby improving the temporal resolution of the olfactory system for detecting dynamic changes of odor plumes in turbulent environments. Altogether, our work unravels a central function of ciliary beating for generating flow fields that increase the sensitivity and the temporal resolution of olfactory computations in the vertebrate brain.
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dnaaf19tn222a/tn222acontrolDay 4
dnaaf19tn222a/tn222acontrolDay 4
dnaaf19tn222a/tn222a; jf5TgcontrolDay 4
dnaaf19tn222a/tn222a; jf5TgcontrolDay 4
dnaaf19tn222a/tn222a; jf5TgcontrolDay 4
dnaaf19tn222a/tn222a; jf5TgcontrolDay 4
dnaaf19tn222a/tn222a; jf5TgcontrolDay 4
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Allele Construct Type Affected Genomic Region
jf5TgTransgenic Insertion
    nkhspggff19bTgTransgenic Insertion
      nkuasgfp1aTgTransgenic Insertion
        nw1TgTransgenic Insertion
          tn222a
            		Point Mutation
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            dnaaf19tn222a/tn222a
            dnaaf19tn222a/tn222a; jf5Tg
            jf5Tg
            nkhspggff19bTg; nkuasgfp1aTg
            nw1Tg
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            Citation
            Reiten, I., Uslu, F.E., Fore, S., Pelgrims, R., Ringers, C., Diaz Verdugo, C., Hoffman, M., Lal, P., Kawakami, K., Pekkan, K., Yaksi, E., Jurisch-Yaksi, N. (2017) Motile-Cilia-Mediated Flow Improves Sensitivity and Temporal Resolution of Olfactory Computations. Current biology : CB. 27(2):166-174.