PUBLICATION

Wnt/ß-catenin signaling Is required for radial glial neurogenesis following spinal cord injury

Authors
Briona, L.K., Poulain, F.E., Mosimann, C., Dorsky, R.I.
ID
ZDB-PUB-150419-6
Date
2015
Source
Developmental Biology   403(1): 15-21 (Journal)
Registered Authors
Dorsky, Richard, Mosimann, Christian, Poulain, Fabienne
Keywords
Injury, Radial glia, Regeneration, Spinal cord, Wnt, Zebrafish
MeSH Terms
  • Spinal Cord Injuries/physiopathology*
  • Wnt Signaling Pathway
  • Neurons/metabolism
  • Zebrafish Proteins/metabolism
  • Spinal Cord Regeneration/physiology*
  • Zebrafish
  • Ependymoglial Cells/cytology
  • Ependymoglial Cells/metabolism*
  • Neuroglia/metabolism
  • Spinal Cord/metabolism
  • Wnt Proteins/metabolism*
  • Animals
  • beta Catenin/metabolism*
  • Animals, Genetically Modified
  • Neurogenesis
  • Axons/metabolism
(all 16)
PubMed
25888075 Full text @ Dev. Biol.
Abstract
Spinal cord injury results in permanent sensorimotor loss in mammals, in part due to a lack of injury-induced neurogenesis. The regeneration of neurons depends upon resident neural progenitors, which in zebrafish persist throughout the central nervous system as radial glia. However the molecular mechanisms regulating spinal cord progenitors remain uncharacterized. Wnt/ß-catenin signaling is necessary for the regenerative response of multiple tissues in zebrafish as well as other vertebrates, but it is not known whether the pathway has a role in spinal cord regeneration. Here we show that spinal radial glia exhibit Wnt/ß-catenin activity as they undergo neurogenesis following transection. We then use Cre-mediated lineage tracing to label the progeny of radial glia and show that Wnt/ß-catenin signaling is required for progenitors to differentiate into neurons. Finally, we show that axonal regrowth after injury also requires Wnt/ß-catenin signaling, suggesting coordinated roles for the pathway in functional recovery. Our data thus establish Wnt/ß-catenin pathway activation as a necessary step in spinal cord regeneration.
Genes / Markers
Figures
Figure Gallery (3 images)
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Expression
No data available
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
cz1701TgTransgenic Insertion
    ia4TgTransgenic Insertion
      knu3TgTransgenic Insertion
        w32TgTransgenic Insertion
          zd16TgTransgenic Insertion
            1 - 5 of 5
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            Human Disease / Model
            No data available
            Sequence Targeting Reagents
            No data available
            Fish
            Fish
            zd16Tg
            1 - 1 of 1
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            Antibodies
            Orthology
            No data available
            Engineered Foreign Genes
            Marker Marker Type Name
            CreEFGCre
            EGFPEFGEGFP
            GFPEFGGFP
            mCherryEFGmCherry
            YFPEFGYFP
            1 - 5 of 5
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            Mapping
            No data available