PUBLICATION
Temporal and spatial expression analysis of peripheral myelin protein 22 (Pmp22) in developing Xenopus
- Authors
- Tae, H.J., Rahman, M.M., Park, B.Y.
- ID
- ZDB-PUB-150124-1
- Date
- 2015
- Source
- Gene expression patterns : GEP 17(1): 26-30 (Journal)
- Registered Authors
- Keywords
- Pmp22, Xenopus, cranio-facial cartilages, otic vesicle, trigeminal ganglia
- MeSH Terms
-
- Molecular Sequence Data
- Myelin Proteins/chemistry
- Myelin Proteins/metabolism*
- Cartilage/metabolism
- Central Nervous System/metabolism
- Gene Expression Regulation, Developmental*
- Amino Acid Sequence
- Xenopus Proteins/chemistry
- Xenopus Proteins/metabolism*
- Animals
- Base Sequence
- Sequence Analysis, DNA
- Xenopus/growth & development*
- PubMed
- 25616247 Full text @ Gene Expr. Patterns
Citation
Tae, H.J., Rahman, M.M., Park, B.Y. (2015) Temporal and spatial expression analysis of peripheral myelin protein 22 (Pmp22) in developing Xenopus. Gene expression patterns : GEP. 17(1):26-30.
Abstract
Peripheral myelin protein 22 (Pmp22), a member of the junction protein family Claudin/EMP/PMP22, contributes to the formation and maintenance of myelin sheaths in the peripheral nervous system. Apart from the establishment and maintenance of peripheral nerves, Pmp22 and its family member have also been participated in a broad range of more general process including cell cycle regulation and apoptosis during development. Pmp22 has been identified from several vertebrate species including mouse, human and zebrafish. However, Pmp22 has not been identified from Xenopus embryos yet. In this paper, we cloned Pmp22 from Xenopus laevis and evaluated its expression during embryogenesis. We found that Pmp22 was initially expressed in the mesoderm and cement gland during the neurula stage. At early tailbud stage, strong expression of Pmp22 was detected in the trigeminal and profundal ganglia as well as developing somites and branchial arches. Later in development, Pmp22 was expressed specifically in cranio-facial cartilage, roof plate and floor plate of the developing brain, otic vesicle and lens. Pmp22 is also strongly expressed in the developing trachea and lungs. Based on its expression in facial tissues, we propose that Pmp22 may be involved in the formation of head structure in addition to the maintenance of functional peripheral nerves in Xenopus embryos.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping