PUBLICATION

Spatial Regionalization and Heterochrony in the Formation of Adult Pallial Neural Stem Cells

Authors
Dirian, L., Galant, S., Coolen, M., Chen, W., Bedu, S., Houart, C., Bally-Cuif, L., Foucher, I.
ID
ZDB-PUB-140716-17
Date
2014
Source
Developmental Cell   30(2): 123-36 (Journal)
Registered Authors
Bally-Cuif, Laure, Bedu, Sebastien, Chen, Wenbiao, Coolen, Marion, Dirian, Lara, Foucher, Isabelle, Houart, Corinne
Keywords
none
MeSH Terms
  • Promoter Regions, Genetic
  • Transcription, Genetic
  • Organ Specificity
  • Neuroglia/cytology
  • Neuroglia/metabolism
  • Adult Stem Cells/cytology*
  • Adult Stem Cells/metabolism
  • Neurons/cytology
  • Neurons/metabolism
  • Neurogenesis
  • Cell Lineage*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
  • Neural Stem Cells/cytology*
  • Neural Stem Cells/metabolism
  • Globus Pallidus/cytology*
  • Globus Pallidus/embryology
  • Globus Pallidus/growth & development
  • Embryonic Stem Cells/cytology
  • Embryonic Stem Cells/metabolism
  • Animals
  • Zebrafish
  • Gene Expression Regulation, Developmental
(all 23)
PubMed
25017692 Full text @ Dev. Cell
Abstract
Little is known on the embryonic origin and related heterogeneity of adult neural stem cells (aNSCs). We use conditional genetic tracing, activated in a global or mosaic fashion by cell type-specific promoters or focal laser uncaging, coupled with gene expression analyses and Notch invalidations, to address this issue in the zebrafish adult telencephalon. We report that the germinal zone of the adult pallium originates from two distinct subtypes of embryonic progenitors and integrates two modes of aNSC formation. Dorsomedial aNSCs derive from the amplification of actively neurogenic radial glia of the embryonic telencephalon. On the contrary, the lateral aNSC population is formed by stepwise addition at the pallial edge from a discrete neuroepithelial progenitor pool of the posterior telencephalic roof, activated at postembryonic stages and persisting lifelong. This dual origin of the pallial germinal zone allows the temporally organized building of pallial territories as a patchwork of juxtaposed compartments.
Genes / Markers
Figures
Figure Gallery (7 images)
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Expression
No data available
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
a131TgTransgenic Insertion
    cz1701TgTransgenic Insertion
      cz1702TgTransgenic Insertion
        vu298aTgTransgenic Insertion
          y83TgTransgenic Insertion
            1 - 5 of 5
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            Human Disease / Model
            No data available
            Sequence Targeting Reagents
            No data available
            Fish
            Fish
            a131Tg; cz1702Tg
            cz1701Tg
            cz1702Tg
            vu298aTg
            y83Tg
            1 - 5 of 5
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            Antibodies
            Orthology
            No data available
            Engineered Foreign Genes
            Marker Marker Type Name
            CFPEFGCFP
            CreEFGCre
            EGFPEFGEGFP
            mCherryEFGmCherry
            RFPEFGRFP
            YFPEFGYFP
            1 - 6 of 6
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            Mapping
            No data available
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            Citation
            Dirian, L., Galant, S., Coolen, M., Chen, W., Bedu, S., Houart, C., Bally-Cuif, L., Foucher, I. (2014) Spatial Regionalization and Heterochrony in the Formation of Adult Pallial Neural Stem Cells. Developmental Cell. 30(2):123-36.