PUBLICATION

The Epicardium in the Embryonic and Adult Zebrafish

Authors
Peralta, M., González-Rosa, J.M., Marques, I.J., Mercader, N.
ID
ZDB-PUB-140614-4
Date
2014
Source
Journal of developmental biology   2: 101-116 (Journal)
Registered Authors
Marques, Ines, Mercader Huber, Nadia, Peralta López, Marina
Keywords
development, epicardium, proepicardium, regeneration, wt1a, wt1b, zebrafish
MeSH Terms
none
PubMed
24926432 Full text @ J Dev Biol
Abstract
The epicardium is the mesothelial outer layer of the vertebrate heart. It plays an important role during cardiac development by, among other functions, nourishing the underlying myocardium, contributing to cardiac fibroblasts and giving rise to the coronary vasculature. The epicardium also exerts key functions during injury responses in the adult and contributes to cardiac repair. In this article, we review current knowledge on the cellular and molecular mechanisms underlying epicardium formation in the zebrafish, a teleost fish, which is rapidly gaining status as an animal model in cardiovascular research, and compare it with the mechanisms described in other vertebrate models. We moreover describe the expression patterns of a subset of available zebrafish Wilms' tumor 1 transgenic reporter lines and discuss their specificity, applicability and limitations in the study of epicardium formation.
Genes / Markers
Figures
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Expression
Phenotype
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Mutations / Transgenics
Allele Construct Type Affected Genomic Region
cn1EtTransgenic Insertion
    li1TgTransgenic Insertion
      li7TgTransgenic Insertion
        li13TgTransgenic Insertion
          um13TgTransgenic Insertion
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            Fish
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            Antibodies
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            Engineered Foreign Genes
            Marker Marker Type Name
            DsRedEFGDsRed
            DsRedxEFGDsRedx
            EGFPEFGEGFP
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            Mapping