PUBLICATION

Dermal fin rays and scales derive from mesoderm, not neural crest

Authors
Lee, R., Thiery, J.P., and Carney, T.J.
ID
ZDB-PUB-130610-36
Date
2013
Source
Current biology : CB   23(9): R336-337 (Journal)
Registered Authors
Carney, Tom, Lee, Raymond
Keywords
none
MeSH Terms
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish/metabolism
  • Neural Crest/embryology*
  • Bone and Bones/embryology*
  • Mesoderm/embryology
  • Animals, Genetically Modified/embryology
  • Animals, Genetically Modified/genetics
  • Animals, Genetically Modified/metabolism
  • Promoter Regions, Genetic
  • Animals
  • Fish Proteins/genetics*
  • Fish Proteins/metabolism
  • Skin/embryology
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism
  • Integrases/genetics
  • Integrases/metabolism
  • SOXE Transcription Factors/genetics
  • SOXE Transcription Factors/metabolism
  • Animal Fins/embryology
(all 21)
PubMed
23660348 Full text @ Curr. Biol.
Abstract

Neural crest cells disperse throughout the embryonic head to generate diverse cell types of two classes: non-ectomesenchymal (including melanocytes, peripheral neurons and glia) and ectomesenchymal (skeletogenic, odontogenic, cartilaginous and connective tissue cell fates). In contrast to cranial neural crest, trunk neural crest of amniotes generates only non-ectomesenchymal cell types. Anamniote trunk neural crest, however, has been assumed to generate derivatives of both classes, including osteoblasts of dermal skeletal elements, which includes scales and fin rays. Through genetic lineage tracing in zebrafish, we present the first test of this assumption and find that trunk neural crest does not generate fin osteoblasts; rather, these derive from a late emerging population of paraxial mesoderm. Similarly we show that the mineralising cells of the scales are mesodermally derived, with no contribution from neural crest. Our data suggest that trunk/tail exoskeletal structures evolved through deployment of mesodermally derived mesenchyme, rather than neural crest.

Genes / Markers
Figures
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Expression
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Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
cz1701TgTransgenic Insertion
    sq5TgTransgenic Insertion
      sq6TgTransgenic Insertion
        sq7TgTransgenic Insertion
          zf131TgTransgenic Insertion
            1 - 5 of 5
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            Human Disease / Model
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            Sequence Targeting Reagents
            No data available
            Fish
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            Antibodies
            Name Type Antigen Genes Isotypes Host Organism
            Ab1-mbppolyclonalRabbit
            zns-5monoclonal
              IgG1Mouse
              1 - 2 of 2
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              Orthology
              No data available
              Engineered Foreign Genes
              Marker Marker Type Name
              CreEFGCre
              EGFPEFGEGFP
              mCherryEFGmCherry
              1 - 3 of 3
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              Mapping
              No data available