PUBLICATION

Mapping a sensory-motor network onto a structural and functional ground plan in the hindbrain

Authors
Koyama, M., Kinkhabwala, A., Satou, C., Higashijima, S.I., and Fetcho, J.
ID
ZDB-PUB-110110-13
Date
2011
Source
Proceedings of the National Academy of Sciences of the United States of America   108(3): 1170-1175 (Journal)
Registered Authors
Fetcho, Joseph R., Higashijima, Shin-ichi
Keywords
development, locomotion, neuronal circuit, Mauthner neuron
MeSH Terms
  • Rhombencephalon/anatomy & histology
  • Rhombencephalon/physiology*
  • Patch-Clamp Techniques
  • Larva/anatomy & histology
  • Larva/physiology
  • Escape Reaction/physiology*
  • Nerve Net*
  • Body Patterning/physiology*
  • Image Processing, Computer-Assisted
  • Immunohistochemistry
  • Psychomotor Performance/physiology
  • Brain Mapping/methods*
  • Interneurons/metabolism
  • Animals, Genetically Modified
  • Animals
  • Electrophysiology
  • Zebrafish/anatomy & histology
  • Zebrafish/physiology*
(all 18)
PubMed
21199937 Full text @ Proc. Natl. Acad. Sci. USA
Abstract
The hindbrain of larval zebrafish contains a relatively simple ground plan in which the neurons throughout it are arranged into stripes that represent broad neuronal classes that differ in transmitter identity, morphology, and transcription factor expression. Within the stripes, neurons are stacked continuously according to age as well as structural and functional properties, such as axonal extent, input resistance, and the speed at which they are recruited during movements. Here we address the question of how particular networks among the many different sensory-motor networks in hindbrain arise from such an orderly plan. We use a combination of transgenic lines and pairwise patch recording to identify excitatory and inhibitory interneurons in the hindbrain network for escape behaviors initiated by the Mauthner cell. We map this network onto the ground plan to show that an individual hindbrain network is built by drawing components in predictable ways from the underlying broad patterning of cell types stacked within stripes according to their age and structural and functional properties. Many different specialized hindbrain networks may arise similarly from a simple early patterning.
Genes / Markers
Figures
Figure Gallery (5 images)
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Expression
No data available
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
cf3TgTransgenic Insertion
    cf4TgTransgenic Insertion
      nns13aTgTransgenic Insertion
        nns14TgTransgenic Insertion
          ts25
            		Point Mutation
            zf139TgTransgenic Insertion
              1 - 6 of 6
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              Human Disease / Model
              No data available
              Sequence Targeting Reagents
              No data available
              Fish
              Fish
              cacnb1ts25/ts25
              cf3Tg/cf3Tg; cf4Tg/cf4Tg
              nns13aTg
              nns14Tg
              zf139Tg
              1 - 5 of 5
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              Antibodies
              No data available
              Orthology
              No data available
              Engineered Foreign Genes
              Marker Marker Type Name
              CreEFGCre
              DsRedEFGDsRed
              EGFPEFGEGFP
              GFPEFGGFP
              mCherryEFGmCherry
              1 - 5 of 5
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              Mapping
              No data available
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              Citation
              Koyama, M., Kinkhabwala, A., Satou, C., Higashijima, S.I., and Fetcho, J. (2011) Mapping a sensory-motor network onto a structural and functional ground plan in the hindbrain. Proceedings of the National Academy of Sciences of the United States of America. 108(3):1170-1175.