PUBLICATION

Dermal morphogenesis controls lateral line patterning during postembryonic development of teleost fish

Authors
Wada, H., Ghysen, A., Satou, C., Higashijima, S.I., Kawakami, K., Hamaguchi, S., and Sakaizumi, M.
ID
ZDB-PUB-100223-53
Date
2010
Source
Developmental Biology   340(2): 583-594 (Journal)
Registered Authors
Ghysen, Alain, Higashijima, Shin-ichi, Kawakami, Koichi, Wada, Hironori
Keywords
Lateral line, Neuromast, Postembryonic development, Dermal bone, Opercle, scale, Zebrafish, Medaka
MeSH Terms
  • Animals
  • Microscopy, Video
  • Bone and Bones/embryology
  • Animals, Genetically Modified
  • Microinjections
  • Oligonucleotides, Antisense/metabolism
  • Body Patterning*
  • Mechanoreceptors/cytology
  • Oryzias/embryology
  • Oryzias/growth & development*
  • Zebrafish/embryology
  • Zebrafish/growth & development*
  • Dermis/cytology
  • Dermis/growth & development
  • Immunohistochemistry
  • Lateral Line System/cytology
  • Lateral Line System/growth & development*
  • Embryo, Nonmammalian
  • Models, Biological
  • Species Specificity
  • Morphogenesis*
  • In Situ Hybridization
(all 22)
PubMed
20171200 Full text @ Dev. Biol.
Abstract
The lateral line system displays highly divergent patterns in adult teleost fish. The mechanisms underlying this variability are poorly understood. Here, we demonstrate that the lateral line mechanoreceptor, the neuromast, gives rise to a series of accessory neuromasts by a serial budding process during postembryonic development in zebrafish. We also show that accessory neuromast formation is highly correlated to the development of underlying dermal structures such as bones and scales. Abnormalities in opercular bone morphogenesis, in endothelin 1-knockdown embryos, is accompanied by stereotypic errors in neuromast budding and positioning, further demonstrating the tight correlation between the patterning of neuromasts and of the underlying dermal bones. In medaka, where scales form between peridermis and opercular bones, the lateral line displays a scale-specific pattern which is never observed in zebrafish. These results strongly suggest a control of postembryonic neuromast patterns by underlying dermal structures. This dermal control may explain some aspects of the evolution of lateral line patterns.
Genes / Markers
Figures
Figure Gallery (12 images) / 2
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Expression
Phenotype
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
nkhg21cEtTransgenic Insertion
nkhgn39dEtTransgenic Insertion
nns8TgTransgenic Insertion
    rw0TgTransgenic Insertion
      zf106TgTransgenic Insertion
        1 - 5 of 5
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        Human Disease / Model
        No data available
        Sequence Targeting Reagents
        Target Reagent Reagent Type
        edn1MO1-edn1MRPHLNO
        neurog1MO1-neurog1MRPHLNO
        1 - 2 of 2
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        Fish
        Antibodies
        Name Type Antigen Genes Isotypes Host Organism
        Ab1-tubamonoclonal
          IgG2bMouse
          1 - 1 of 1
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          Orthology
          No data available
          Engineered Foreign Genes
          Marker Marker Type Name
          EGFPEFGEGFP
          GFPEFGGFP
          TomatoEFGTomato
          1 - 3 of 3
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          Mapping
          No data available