PUBLICATION

psoriasis regulates epidermal development in zebrafish

Authors
Webb, A.E., Driever, W., and Kimelman, D.
ID
ZDB-PUB-080327-1
Date
2008
Source
Developmental Dynamics : an official publication of the American Association of Anatomists   237(4): 1153-1164 (Journal)
Registered Authors
Driever, Wolfgang, Kimelman, David, Webb, Ashley
Keywords
zebrafish, epidermis, keratinocyte, proliferation
MeSH Terms
  • Cell Polarity
  • Keratins/genetics
  • Keratins/metabolism
  • Zebrafish/anatomy & histology
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Cell Death/physiology
  • Genes
  • Mutation*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
  • Epidermis/embryology*
  • Epidermis/growth & development
  • Epidermis/metabolism*
  • Cell Differentiation
  • Animals
  • Cell Proliferation
  • Keratinocytes/cytology
  • Keratinocytes/physiology
(all 19)
PubMed
18351656 Full text @ Dev. Dyn.
Abstract
The zebrafish epidermis completely envelopes the embryo by 14 hours postfertilization, providing an essential barrier between the internal organs and the environment. As the embryo increases in size, keratinocytes in the epidermis must proliferate and differentiate to form the three epidermal layers present in the adult. The mechanisms controlling growth, differentiation, and maintenance of the fish epidermis are mostly unknown. Here, we describe psoriasis, an epidermal mutant that exhibits widespread overproliferation of the epidermis at 3 days postfertilization and a defect in keratinocyte differentiation. Based on mosaic analysis, we show that psoriasis acts non-cell-autonomously, suggesting that psoriasis encodes a secreted factor. Our analysis of the psoriasis mutant indicates that keratinocyte differentiation and proliferation are tightly regulated to maintain a cohesive epidermal sheet around the embryo and that disruptions in these processes result in the formation of epidermal aggregates.
Genes / Markers
Figures
Figure Gallery (6 images)
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Expression
Phenotype
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
m14
    Point Mutation
    1 - 1 of 1
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    Human Disease / Model
    No data available
    Sequence Targeting Reagents
    No data available
    Fish
    1 - 2 of 2
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    Antibodies
    Name Type Antigen Genes Isotypes Host Organism
    Ab1-krtmonoclonal
      IgG2aMouse
      Ab1-pan-CadherinpolyclonalRabbit
      Ab1-tp63monoclonalIgG2aMouse
      1 - 3 of 3
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      Orthology
      No data available
      Engineered Foreign Genes
      No data available
      Mapping
      Entity Type Entity Symbol Location
      Featurem14Chr: 6 Details
      GENEactl6aChr: 6 Details
      SSLPz12094Chr: 6 Details
      1 - 3 of 3
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