PUBLICATION

Fgf19 regulated by Hh signaling is required for zebrafish forebrain development

Authors
Miyake, A., Nakayama, Y., Konishi, M., and Itoh, N.
ID
ZDB-PUB-051101-14
Date
2005
Source
Developmental Biology   288(1): 259-275 (Journal)
Registered Authors
Itoh, Nobuyuki, Konishi, Morichika, Miyake, Ayumi, Nakayama, Yoshiaki
Keywords
Fgf, Fgf19, Fgf3, Fgf8, Hh; Zebrafish, Regionalization, Cell proliferation, Neuronal differentiation, Forebrain
MeSH Terms
  • Molecular Sequence Data
  • Cell Survival/physiology
  • Mesencephalon/embryology
  • Mesencephalon/metabolism
  • Zebrafish/embryology*
  • Zebrafish/metabolism
  • Cerebellum/embryology
  • Zebrafish Proteins/deficiency
  • Zebrafish Proteins/metabolism
  • Zebrafish Proteins/physiology*
  • Cell Differentiation/physiology
  • Fibroblast Growth Factors/deficiency
  • Fibroblast Growth Factors/metabolism
  • Fibroblast Growth Factors/physiology*
  • Up-Regulation
  • Signal Transduction/genetics
  • Signal Transduction/physiology*
  • Rhombencephalon/embryology
  • Rhombencephalon/metabolism
  • Amino Acid Sequence
  • Interneurons/cytology
  • Interneurons/metabolism
  • Oligodendroglia/cytology
  • Oligodendroglia/metabolism
  • Hedgehog Proteins
  • Prosencephalon/abnormalities
  • Prosencephalon/embryology
  • Prosencephalon/metabolism*
  • Cell Proliferation
  • Trans-Activators/physiology*
  • GABA Agents/metabolism
  • Gene Expression Profiling
  • Animals
  • Thalamus/embryology
  • Thalamus/physiology
  • Sequence Analysis, Protein
(all 36)
PubMed
16256099 Full text @ Dev. Biol.
Abstract
Fibroblast growth factor (Fgf) signaling plays important roles in brain development. Fgf3 and Fgf8 are crucial for the formation of the forebrain and hindbrain. Fgf8 is also required for the midbrain to form. Here, we identified zebrafish Fgf19 and examined its roles in brain development by knocking down Fgf19 function. We found that Fgf19 expressed in the forebrain, midbrain and hindbrain was involved in cell proliferation and cell survival during embryonic brain development. Fgf19 was also essential for development of the ventral telencephalon and diencephalon. Regional specification is linked to cell type specification. Fgf19 was also essential for the specification of gamma-aminobutyric acid (GABA)ergic interneurons and oligodendrocytes generated in the ventral telencephalon and diencephalon. The cross talk between Fgf and Hh signaling is critical for brain development. In the forebrain, Fgf19 expression was down-regulated on inhibition of Hh but not of Fgf3/Fgf8, and overexpression of Fgf19 rescued partially the phenotype on inhibition of Hh. The present findings indicate that Fgf19 signaling is crucial for forebrain development by interacting with Hh and provide new insights into the roles of Fgf signaling in brain development.
Genes / Markers
Figures
Figure Gallery (8 images)
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Expression
Phenotype
No data available
Mutations / Transgenics
No data available
Human Disease / Model
No data available
Sequence Targeting Reagents
Target Reagent Reagent Type
fgf3MO1-fgf3MRPHLNO
fgf8aMO3-fgf8aMRPHLNO
fgf19MO1-fgf19MRPHLNO
1 - 3 of 3
Show
Fish
Fish
WT
WT + MO1-fgf3 + MO3-fgf8a
WT + MO1-fgf19
1 - 3 of 3
Show
Antibodies
No data available
Orthology
Gene Orthology
fgf19
1 - 1 of 1
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Engineered Foreign Genes
No data available
Mapping
No data available
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Citation
Miyake, A., Nakayama, Y., Konishi, M., and Itoh, N. (2005) Fgf19 regulated by Hh signaling is required for zebrafish forebrain development. Developmental Biology. 288(1):259-275.