PUBLICATION
No correlation between multilamellar bodies in the inner ear and further organs of mutant (backstroke, bks) and wildtype zebrafish embryos
- Authors
- Anken, R., Ibsch, M., Kniesel, U., and Rahmann, H.
- ID
- ZDB-PUB-050411-1
- Date
- 2004
- Source
- Advances in space research : the official journal of the Committee on Space Research (COSPAR) 33(8): 1411-1415 (Journal)
- Registered Authors
- Keywords
- Utricle; Saccule; Otolith; Myelinated bodies; Myelin figures
- MeSH Terms
-
- Epithelium/ultrastructure*
- Organelles/ultrastructure*
- Microscopy, Electron, Transmission
- Otolithic Membrane/ultrastructure*
- Embryo, Nonmammalian
- Zebrafish/anatomy & histology
- Zebrafish/embryology*
- Zebrafish/genetics
- Animals
- Acoustic Maculae/ultrastructure*
- PubMed
- 15803637 Full text @ Adv. Space Res.
Citation
Anken, R., Ibsch, M., Kniesel, U., and Rahmann, H. (2004) No correlation between multilamellar bodies in the inner ear and further organs of mutant (backstroke, bks) and wildtype zebrafish embryos. Advances in space research : the official journal of the Committee on Space Research (COSPAR). 33(8):1411-1415.
Abstract
The origin of the proteinacious matrix of the inner ear stones (otoliths) of vertebrates has not yet been clarified. Using the backstroke mutant (bks) of the zebrafish Danio rerio, which is characterized by a complete lack of otoliths, we searched for possibly missing or aberrant structural components within the macular epithelia of the inner ears of embryos on the ultrastructural level. Numerous multilamellar bodies (MLBs) were found. The MLBs were, however, not restricted to the inner ears of mutants but were also found in wildtype individuals and in further organs such as brain and liver. MLBs have hitherto never been described from the inner ear of fish and are generally estimated to be rare structures. Their occurrence in fish liver can, however, be induced by using particular chemical substances, which seem to effect adaptive compensatory processes on the cellular level. Such a chemical treatment also affects the ultrastructure of further organelles. Since the occurrence of MLBs in the liver of zebrafish was not accompanied by an alteration of the morphology of other organelles, their occurrence seems not to be due to environmental stress. The findings indicate that the MLBs cannot be correlated with bks-inherent features as well as with missing otolith development/growth. Since the occurrence of MLBs was independent from the developmental stage of a specimen and its overall tissue preservation, it can moreover be excluded that these MLBs merely represent fixation artifacts. Their presence more likely indicates cellular remodelling processes of hitherto unknown significance. c2003 COSPAR. Published by Elsevier Ltd. All rights reserved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping