PUBLICATION

Delta signaling mediates segregation of neural crest and spinal sensory neurons from zebrafish lateral neural plate

Authors
Cornell, R.A. and Eisen, J.S.
ID
ZDB-PUB-000810-1
Date
2000
Source
Development (Cambridge, England)   127(13): 2873-2882 (Journal)
Registered Authors
Cornell, Robert, Eisen, Judith S.
Keywords
zebrafish; neural crest; Delta; notch; deltaA
MeSH Terms
  • Genotype
  • Spinal Nerves/embryology*
  • Membrane Proteins/genetics
  • Membrane Proteins/metabolism*
  • In Situ Hybridization
  • Animals
  • Neurons/cytology
  • Neurons/metabolism
  • Transcription Factors/biosynthesis
  • Cell Movement
  • Pigmentation/physiology
  • Point Mutation
  • Skull/embryology
  • Spinal Cord/embryology
  • beta-Galactosidase/metabolism
  • Mesoderm/metabolism
  • Gene Expression Regulation, Developmental*
  • Neural Crest/embryology*
  • Signal Transduction
  • Intracellular Signaling Peptides and Proteins
  • Zebrafish/embryology*
  • Immunohistochemistry
(all 22)
PubMed
10851132 Full text @ Development
Abstract
We examined the role of Delta signaling in specification of two derivatives in zebrafish neural plate: Rohon-Beard spinal sensory neurons and neural crest. deltaA-expressing Rohon-Beard neurons are intermingled with premigratory neural crest cells in the trunk lateral neural plate. Embryos homozygous for a point mutation in deltaA, or with experimentally reduced Delta signaling, have supernumerary Rohon-Beard neurons, reduced trunk-level expression of neural crest markers and lack trunk neural crest derivatives. Fin mesenchyme, a putative trunk neural crest derivative, is present in deltaA mutants, suggesting it segregates from other neural crest derivatives as early as the neural plate stage. Cranial neural crest derivatives are also present in deltaA mutants, revealing a genetic difference in regulation of trunk and cranial neural crest development.
Genes / Markers
Figures
No images available
Expression
No data available
Phenotype
No data available
Mutations / Transgenics
Allele Construct Type Affected Genomic Region
dx2
    		Point Mutation
    1 - 1 of 1
    Show
    Human Disease / Model
    No data available
    Sequence Targeting Reagents
    No data available
    Fish
    Antibodies
    Orthology
    Engineered Foreign Genes
    No data available
    Mapping
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    Citation
    Cornell, R.A. and Eisen, J.S. (2000) Delta signaling mediates segregation of neural crest and spinal sensory neurons from zebrafish lateral neural plate. Development (Cambridge, England). 127(13):2873-2882.