Person
Drapeau, Pierre
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Biography and Research Interest
As a model for the formation and function of CNS circuits, we are studying the development of the locomotor network in manipulable zebrafish embryos by combining cellular neurophysiology and molecular genetics. We record and image the activity patterns of identified neurons during development in wild-type and genetically modified embryos, including by transgenic over-expression, upon antisense knockdown and in mutations that affect locomotion. Our goal is to elucidate the molecular choreography of locomotor network formation and function. We are also using the zebrafish as a model for the validation of mutations and screening of potential therapeutics for human genes linked by genomic analyses to neurological and psychiatric developmental disorders.
- Wang, M., Zhao, S., Shi, C., Guyot, M.C., Liao, M., Tauer, J.T., Willie, B.M., Cobetto, N., Aubin, C.É., Küster-Schöck, E., Drapeau, P., Zhang, J., Wu, N., Kibar, Z. (2025) Correction: Planar cell polarity zebrafish models of congenital scoliosis reveal underlying defects in notochord morphogenesis. Development (Cambridge, England). 152:
- Wang, M., Zhao, S., Shi, C., Guyot, M.C., Liao, M., Tauer, J.T., Willie, B.M., Cobetto, N., Aubin, C.É., Küster-Schöck, E., Drapeau, P., Zhang, J., Wu, N., Kibar, Z. (2024) Planar cell polarity zebrafish models of congenital scoliosis reveal novel underlying defects in notochord morphogenesis. Development (Cambridge, England). 151(21):
- Bekri, A., Liao, M., Drapeau, P. (2019) Glycine Regulates Neural Stem Cell Proliferation During Development via Lnx1-Dependent Notch Signaling. Frontiers in molecular neuroscience. 12:44
- Bose, P., Tremblay, E., Maois, C., Narasimhan, V., Armstrong, G.A.B., Liao, M., Parker, J.A., Robitaille, R., Wen, X.Y., Barden, C., Drapeau, P. (2019) The Novel Small Molecule TRVA242 Stabilizes Neuromuscular Junction Defects in Multiple Animal Models of Amyotrophic Lateral Sclerosis. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 16(4):1149-1166
- Samarut, E., Chalopin, D., Riché, R., Allard, M., Liao, M., Drapeau, P. (2019) Individual knock out of glycine receptor alpha subunits identifies a specific requirement of glra1 for motor function in zebrafish. PLoS One. 14:e0216159
- Samarut, É., Nixon, J., Kundap, U.P., Drapeau, P., Ellis, L.D. (2019) Single and Synergistic Effects of Cannabidiol and Δ-9-Tetrahydrocannabinol on Zebrafish Models of Neuro-Hyperactivity. Frontiers in pharmacology. 10:226
- Swaminathan, A., Basu, M., Bekri, A., Drapeau, P., Kundu, T.K. (2019) The Dietary Flavonoid, Luteolin, Negatively Affects Neuronal Differentiation. Frontiers in molecular neuroscience. 12:41
- Bekri, A., Drapeau, P. (2018) Glycine Promotes the Survival of a Subpopulation of Neural Stem Cells. Frontiers in cell and developmental biology. 6:68
- Bose, P., Armstrong, G.A.B., Drapeau, P. (2018) Neuromuscular junction abnormalities in a zebrafish loss-of-function model of TDP-43. Journal of neurophysiology. 121(1):285-297
- Lissouba, A., Liao, M., Kabashi, E., Drapeau, P. (2018) Transcriptomic Analysis of Zebrafish TDP-43 Transgenic Lines. Frontiers in molecular neuroscience. 11:463
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Non-Zebrafish Publications