ZFIN Morpholino: MO1-atg5

Target Location

Genome Build: GRCz11Chromosome: 16

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-atg5

No data available

Phenotype

Phenotype resulting from MO1-atg5

Phenotype	Fish	Figures
blood decreased volume, abnormal	TU + MO1-atg5	Fig. 3 from Hu et al., 2011
common cardinal vein congested, abnormal	TU + MO1-atg5	Fig. 3 from Hu et al., 2011
diencephalon dopaminergic neuron decreased amount, abnormal	AB + MO1-atg5	Fig. 5, Fig. 6 from Hu et al., 2017
dopaminergic neuron decreased amount, abnormal	AB + MO1-atg5	Fig. 4 from Hu et al., 2017
embryo development disrupted, abnormal	TU + MO1-atg5	Fig. 3 from Hu et al., 2011

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Phenotype of all Fish created by or utilizing MO1-atg5

Phenotype	Fish	Conditions	Figures
diencephalon dopaminergic neuron decreased amount, abnormal	AB + MO1-atg5	control	Fig. 5, Fig. 6 from Hu et al., 2017
whole organism ab3-map1lc3b labeling decreased amount, abnormal	AB + MO1-atg5	control	Figure 5 from Inoue et al., 2021
dopaminergic neuron decreased amount, exacerbated	AB + MO1-atg5	chemical treatment by environment: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	Fig. 4 from Hu et al., 2017
swimming decreased process quality, exacerbated	AB + MO1-atg5	chemical treatment by environment: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine	Fig. 7 from Hu et al., 2017
whole organism ab1-atg5 labeling decreased amount, abnormal	AB + MO1-atg5	control	Fig. 3 from Hu et al., 2017

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Citations

Include unpublished citations

Giong, H.K., Hyeon, S.J., Lee, J.G., Cho, H.J., Park, U., Stein, T.D., Lee, J., Yu, K., Ryu, H., Lee, J.S. (2024) Tau accumulation is cleared by the induced expression of VCP via autophagy. Acta Neuropathologica. 148:4646
Chen, X.K., Yi, Z.N., Lau, J.J., Ma, A.C. (2023) Distinct roles of core autophagy-related genes in zebrafish definitive hematopoiesis. Autophagy. 20(4):830-846
Inoue, M., Miyahara, H., Shiraishi, H., Shimizu, N., Tsumori, M., Kiyota, K., Maeda, M., Umeda, R., Ishitani, T., Hanada, R., Ihara, K., Hanada, T. (2021) Leucyl-tRNA synthetase deficiency systemically induces excessive autophagy in zebrafish. Scientific Reports. 11:8392
Masud, S., Prajsnar, T.K., Torraca, V., Lamers, G.E.M., Benning, M., Van Der Vaart, M., Meijer, A.H. (2019) Macrophages target Salmonella by Lc3-associated phagocytosis in a systemic infection model. Autophagy. 15(5):796-812
Hu, Z.Y., Chen, B., Zhang, J.P., Ma, Y.Y. (2017) Up-regulation of autophagy-related gene 5 (ATG5) protects dopaminergic neurons in a zebrafish model of Parkinson's disease.. The Journal of biological chemistry. 292(44):18062-18074
Mans, L.A., Querol Cano, L., van Pelt, J., Giardoglou, P., Keune, W.J., Haramis, A.G. (2017) The tumor suppressor LKB1 regulates starvation-induced autophagy under systemic metabolic stress. Scientific Reports. 7:7327
Saera-Vila, A., Kish, P.E., Louie, K.W., Grzegorski, S.J., Klionsky, D.J., Kahana, A. (2016) Autophagy Regulates Cytoplasmic Remodeling During Cell Reprogramming in a Zebrafish Model of Muscle Regeneration. Autophagy. 12(10):1864-1875
Boglev, Y., Badrock, A.P., Trotter, A.J., Du, Q., Richardson, E.J., Parslow, A.C., Markmiller, S.J., Hall, N.E., de Jong-Curtain, T.A., Ng, A.Y., Verkade, H., Ober, E.A., Field, H.A., Shin, D., Shin, C.H., Hannan, K.M., Hannan, R.D., Pearson, R.B., Kim, S.H., Ess, K.C., Lieschke, G.J., Stainier, D.Y., and Heath, J.K. (2013) Autophagy induction is a tor- and tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis. PLoS Genetics. 9(2):e1002379
Hu, Z., Zhang, J., and Zhang, Q. (2011) Expression pattern and functions of autophagy-related gene atg5 in zebrafish organogenesis. Autophagy. 7(12):1514-1527

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