ZFIN Morpholino: MO1-nphp1

Target Location

Genome Build: GRCz11Chromosome: 17

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-nphp1

No data available

Phenotype

Phenotype resulting from MO1-nphp1

Phenotype	Fish	Figures
cloaca development disrupted, abnormal	zf106Tg + MO1-nphp1 + MO4-tp53	Fig. S3 from Slanchev et al., 2011
cloacal chamber distended, abnormal	zf106Tg + MO1-nphp1 + MO4-tp53	Fig. S3 from Slanchev et al., 2011
convergent extension process quality, abnormal	WT + MO1-nphp1	Fig. S1 from Lindstrand et al., 2014
notochord increased width, abnormal	WT + MO1-nphp1	Fig. S1 from Lindstrand et al., 2014
notochord kinked, abnormal	WT + MO1-nphp1	Fig. S1 from Lindstrand et al., 2014

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Phenotype of all Fish created by or utilizing MO1-nphp1

Phenotype	Fish	Conditions	Figures
somite increased width, abnormal	WT + MO1-nphp1	standard conditions	Fig. S1 from Lindstrand et al., 2014
whole organism anterior-posterior axis decreased length, abnormal	WT + MO1-nphp1	standard conditions	Fig. S1 from Lindstrand et al., 2014
notochord kinked, abnormal	WT + MO1-nphp1	standard conditions	Fig. S1 from Lindstrand et al., 2014
notochord increased width, abnormal	WT + MO1-nphp1	standard conditions	Fig. S1 from Lindstrand et al., 2014
convergent extension process quality, abnormal	WT + MO1-nphp1	standard conditions	Fig. S1 from Lindstrand et al., 2014

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Citations

Include unpublished citations

Wang, H., Zaiser, F., Eckert, P., Ruf, J., Kayser, N., Veenstra, A.C., Müller, M., Haas, R., Walz, G., Yakulov, T.A. (2023) Inversin (NPHP2) and Vangl2 are required for normal zebrafish cloaca formation. Biochemical and Biophysical Research Communications. 673:9159-15
Kayser, N., Zaiser, F., Veenstra, A.C., Wang, H., Göcmen, B., Eckert, P., Franz, H., Köttgen, A., Walz, G., Yakulov, T.A. (2022) Clock genes rescue nphp mutations in zebrafish. Human molecular genetics. 31(24):4143-4158
Viau, A., Bienaimé, F., Lukas, K., Todkar, A.P., Knoll, M., Yakulov, T.A., Hofherr, A., Kretz, O., Helmstädter, M., Reichardt, W., Braeg, S., Aschman, T., Merkle, A., Pfeifer, D., Dumit, V.I., Gubler, M.C., Nitschke, R., Huber, T.B., Terzi, F., Dengjel, J., Grahammer, F., Köttgen, M., Busch, H., Boerries, M., Walz, G., Triantafyllopoulou, A., Kuehn, E.W. (2018) Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney. The EMBO journal. 37(15)
Lindstrand, A., Davis, E.E., Carvalho, C.M., Pehlivan, D., Willer, J.R., Tsai, I.C., Ramanathan, S., Zuppan, C., Sabo, A., Muzny, D., Gibbs, R., Liu, P., Lewis, R.A., Banin, E., Lupski, J.R., Clark, R., Katsanis, N. (2014) Recurrent CNVs and SNVs at the NPHP1 Locus Contribute Pathogenic Alleles to Bardet-Biedl Syndrome. American journal of human genetics. 94:745-54
Slanchev, K., Pütz, M., Schmitt, A., Kramer-Zucker, A., and Walz, G. (2011) Nephrocystin-4 is required for pronephric duct-dependent cloaca formation in zebrafish. Human molecular genetics. 20(16):3119-28

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