ZFIN Morpholino: MO1-arl13b

Target Location

Genome Build: GRCz11Chromosome: 1

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-arl13b

No data available

Phenotype

Phenotype resulting from MO1-arl13b

Phenotype	Fish	Figures
axis decreased length, abnormal	WT + MO1-arl13b	Fig. 2 from Duldulao et al., 2009
cerebellar granule cell differentiation decreased occurrence, abnormal	AB + MO1-arl13b	Fig. 3 from Zhu et al., 2020
cerebellar Purkinje cell differentiation decreased occurrence, abnormal	AB + MO1-arl13b	Fig. 4 from Zhu et al., 2020
cerebellum morphogenesis decreased process quality, abnormal	nl1Tg + MO1-arl13b	Fig. 6 from Zhu et al., 2020
convergent extension involved in gastrulation process quality, abnormal	WT + MO1-arl13b	Fig. 2 from Duldulao et al., 2009

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Phenotype of all Fish created by or utilizing MO1-arl13b

Phenotype	Fish	Conditions	Figures
swimming decreased process quality, abnormal	AB + MO1-arl13b	standard conditions	Fig. 1 from Zhu et al., 2020
corpus cerebelli dorso-medial region zic1 expression decreased amount, abnormal	AB + MO1-arl13b	standard conditions	Fig. 3 from Zhu et al., 2020
corpus cerebelli atoh1c expression decreased amount, abnormal	AB + MO1-arl13b	standard conditions	Fig. 2 from Zhu et al., 2020
cerebellar granule cell differentiation decreased occurrence, abnormal	AB + MO1-arl13b	standard conditions	Fig. 3 from Zhu et al., 2020
Purkinje cell layer corpus cerebelli dorso-medial region ab1-pvalb labeling decreased amount, abnormal	AB + MO1-arl13b	standard conditions	Fig. 4 from Zhu et al., 2020

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Citations

Include unpublished citations

Zhu, J., Wang, H.T., Chen, Y.R., Yan, L.Y., Han, Y.Y., Liu, L.Y., Cao, Y., Liu, Z.Z., Xu, H.A. (2020) The Joubert Syndrome Gene arl13b is Critical for Early Cerebellar Development in Zebrafish. Neuroscience Bulletin. 36(9):1023-1034
Jin, M., Wang, D., Xu, W., Wang, H., Cao, Y. (2019) Claudin-7b and Claudin-h are required for controlling cilia morphogenesis in the zebrafish kidney. Mechanisms of Development. 161:103595
Seixas, C., Choi, S.Y., Polgar, N., Umberger, N.L., East, M.P., Zuo, X., Moreiras, H., Ghossoub, R., Benmerah, A., Kahn, R.A., Fogelgren, B., Caspary, T., Lipschutz, J.H., Barral, D.C. (2016) Arl13b and the exocyst interact synergistically in ciliogenesis. Molecular biology of the cell. 27(2):308-20
He, L., Xu, W., Jing, Y., Wu, M., Song, S., Cao, Y., Mei, C. (2015) Yes-Associated Protein (Yap) Is Necessary for Ciliogenesis and Morphogenesis during Pronephros Development in Zebrafish (Danio Rerio). International journal of biological sciences. 11:935-47
Lu, H., Toh, M.T., Narasimhan, V., Thamilselvam, S.K., Choksi, S.P., Roy, S. (2015) A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation. Developmental Biology. 397(2):225-36
Casalou, C., Seixas, C., Portelinha, A., Pintado, P., Barros, M., Ramalho, J.S., Lopes, S.S., Barral, D.C. (2014) Arl13b and the non-muscle myosin heavy chain IIA are required for circular dorsal ruffle formation and cell migration. Journal of Cell Science. 127(Pt 12):2709-22
Duldulao, N.A., Lee, S., and Sun, Z. (2009) Cilia localization is essential for in vivo functions of the Joubert syndrome protein Arl13b/Scorpion. Development (Cambridge, England). 136(23):4033-4042
Sun, Z., Amsterdam, A., Pazour, G.J., Cole, D.G., Miller, M.S. and Hopkins, N. (2004) A Genetic Screen in Zebrafish Identifies Cilia Genes as a Principal Cause of Cystic Kidney Development. Development (Cambridge, England). 131(16):4085-4093

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