ZFIN Morpholino: MO1-duox

Target Location

Genome Build: GRCz11Chromosome: 25

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-duox

No data available

Phenotype

Phenotype resulting from MO1-duox

Phenotype	Fish	Figures
cell death increased occurrence, abnormal	AB + MO1-duox	text only from Niethammer et al., 2009
defense response to fungus process quality, abnormal	i114Tg + MO1-duox + MO4-tp53	Fig. 4 , Fig. 5 from Brothers et al., 2013
neutrophil phagocytosis decreased process quality, abnormal	i114Tg + MO1-duox + MO4-tp53	Fig. 4 from Brothers et al., 2013
neutrophil chemotaxis process quality, abnormal	i114Tg + MO1-duox + MO4-tp53	Fig. 4 from Brothers et al., 2013

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Phenotype of all Fish created by or utilizing MO1-duox

Phenotype	Fish	Conditions	Figures
kidney Ab3-havcr1 labeling increased amount, abnormal	AB + MO1-duox	physical alteration: kidney, chemical treatment by injection: gentamycin	Fig. 2 from Chen et al., 2019
renal tubule hydrogen peroxide amount, ameliorated	AB + MO1-duox	physical alteration: kidney, chemical treatment by injection: gentamycin	Fig. 1 from Chen et al., 2019
renal tubule structure, exacerbated	AB + MO1-duox	physical alteration: kidney, chemical treatment by injection: gentamycin	Fig. 2 from Chen et al., 2019
renal tubule apoptotic process increased occurrence, exacerbated	AB + MO1-duox	physical alteration: kidney, chemical treatment by injection: gentamycin	Fig. 2 from Chen et al., 2019
regenerating tissue kidney lhx1a expression decreased distribution, abnormal	AB + MO1-duox	physical alteration: kidney, chemical treatment by injection: gentamycin	Fig. 3 from Chen et al., 2019

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Citations

Include unpublished citations

Cadiz Diaz, A., Schmidt, N.A., Yamazaki, M., Hsieh, C.J., Lisse, T.S., Rieger, S. (2022) Coordinated NADPH oxidase/hydrogen peroxide functions regulate cutaneous sensory axon de- and regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2115009119
Ma, J., Scott, C.A., Ho, Y.N., Mahabaleshwar, H., Marsay, K.S., Zhang, C., Teow, C.K., Ng, S.S., Zhang, W., Tergaonkar, V., Partridge, L.J., Roy, S., Amaya, E., Carney, T.J. (2021) Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX. eLIFE. 10:
Bernut, A., Loynes, C.A., Floto, R.A., Renshaw, S.A. (2020) Deletion of cftr Leads to an Excessive Neutrophilic Response and Defective Tissue Repair in a Zebrafish Model of Sterile Inflammation. Frontiers in immunology. 11:1733
Katikaneni, A., Jelcic, M., Gerlach, G.F., Ma, Y., Overholtzer, M., Niethammer, P. (2020) Lipid peroxidation regulates long-range wound detection through 5-lipoxygenase in zebrafish. Nature cell biology. 22(9):1049-1055
Chen, J., Yu, T., He, X., Fu, Y., Dai, L., Wang, B., Wu, Y., He, J., Li, Y., Zhang, F., Zhao, J., Liu, C. (2019) Dual roles of hydrogen peroxide in promoting zebrafish renal repair and regeneration. Biochemical and Biophysical Research Communications. 516(3):680-685
LeBert, D., Squirrell, J.M., Freisinger, C., Rindy, J., Golenberg, N., Frecentes, G., Gibson, A., Eliceiri, K.W., Huttenlocher, A. (2018) Damage-induced reactive oxygen species regulate vimentin and dynamic collagen-based projections to mediate wound repair.. eLIFE. 7:e30703
Mendieta-Serrano, M.A., Mendez-Cruz, F.J., Antúnez-Mojica, M., Schnabel, D., Alvarez, L., Cárdenas, L., Lomelí, H., Ruiz-Santiesteban, J.A., Salas-Vidal, E. (2018) NADPH-Oxidase-derived reactive oxygen species are required for cytoskeletal organization, proper localization of E-cadherin and cell motility during zebrafish epiboly. Free radical biology & medicine. 130:82-98
de Oliveira, S., Boudinot, P., Calado, Â., Mulero, V. (2015) Duox1-Derived H2O2 Modulates Cxcl8 Expression and Neutrophil Recruitment via JNK/c-JUN/AP-1 Signaling and Chromatin Modifications. Journal of immunology (Baltimore, Md. : 1950). 194(4):1523-33
Candel, S., de Oliveira, S., López-Muñoz, A., García-Moreno, D., Espín-Palazón, R., Tyrkalska, S.D., Cayuela, M.L., Renshaw, S.A., Corbalán-Vélez, R., Vidal-Abarca, I., Tsai, H.J., Meseguer, J., Sepulcre, M.P., Mulero, V. (2014) Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation. PLoS Biology. 12:e1001855
de Oliveira, S., López-Muñoz, A., Candel, S., Pelegrín, P., Calado, A., Mulero, V. (2014) ATP Modulates Acute Inflammation In Vivo through Dual Oxidase 1-Derived H2O2 Production and NF-kappaB Activation. Journal of immunology (Baltimore, Md. : 1950). 192(12):5710-9

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