ZFIN Morpholino: MO1-apobec2b

Target Location

Genome Build: GRCz11Chromosome: 23

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-apobec2b

No data available

Phenotype

Phenotype resulting from MO1-apobec2b

Phenotype	Fish	Figures
axon regeneration decreased process quality, abnormal	WT + MO1-apobec2b	Fig. 9 from Powell et al., 2012
Muller cell cellular potency, abnormal	mi4Tg + MO1-apobec2b	Fig. 5 from Powell et al., 2012
muscle attachment decreased occurrence, abnormal	AB + MO1-apobec2b	Fig. 5 from Etard et al., 2010
myotome malformed, abnormal	AB + MO1-apobec2b	Fig. 5 from Etard et al., 2010
sensory epithelium regeneration decreased process quality, abnormal	WT + MO1-apobec2b	Fig. 5, Fig. 7 from Powell et al., 2012

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Phenotype of all Fish created by or utilizing MO1-apobec2b

Phenotype	Fish	Conditions	Figures
muscle attachment decreased occurrence, abnormal	AB + MO1-apobec2b	standard conditions	Fig. 5 from Etard et al., 2010
vertical myoseptum malformed, abnormal	AB + MO1-apobec2b	standard conditions	Fig. 5 from Etard et al., 2010
myotome malformed, abnormal	AB + MO1-apobec2b	standard conditions	Fig. 5 from Etard et al., 2010
skeletal muscle organ development process quality, abnormal	AB + MO1-apobec2b	standard conditions	Fig. 5 from Etard et al., 2010
skeletal muscle cell increased length, abnormal	AB + MO1-apobec2b	standard conditions	Fig. 5 from Etard et al., 2010

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Citations

Include unpublished citations

Powell, C., Cornblath, E., Goldman, D. (2014) Zinc-binding Domain-dependent, Deaminase-independent Actions of Apolipoprotein B mRNA-editing Enzyme, Catalytic Polypeptide 2 (Apobec2), Mediate Its Effect on Zebrafish Retina Regeneration. The Journal of biological chemistry. 289(42):28924-41
Powell, C., Grant, A.R., Cornblath, E., and Goldman, D. (2013) Analysis of DNA methylation reveals a partial reprogramming of the Muller glia genome during retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 110(49):19814-19819
Powell, C., Elsaeidi, F., and Goldman, D. (2012) Injury-Dependent Muller Glia and Ganglion Cell Reprogramming during Tissue Regeneration Requires Apobec2a and Apobec2b. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(3):1096-1109
Etard, C., Roostalu, U., and Strähle, U. (2010) Lack of Apobec2-related proteins causes a dystrophic muscle phenotype in zebrafish embryos. The Journal of cell biology. 189(3):527-539
Rai, K., Sarkar, S., Broadbent, T.J., Voas, M., Grossmann, K.F., Nadauld, L.D., Dehghanizadeh, S., Hagos, F.T., Li, Y., Toth, R.K., Chidester, S., Bahr, T.M., Johnson, W.E., Sklow, B., Burt, R., Cairns, B.R., and Jones, D.A. (2010) DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC. Cell. 142(6):930-942
Rai, K., Huggins, I.J., James, S.R., Karpf, A.R., Jones, D.A., and Cairns, B.R. (2008) DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell. 135(7):1201-1212

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