ZFIN Morpholino: MO1-rab11a

Target Location

Genome Build: GRCz11Chromosome: 18

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-rab11a

No data available

Phenotype

Phenotype resulting from MO1-rab11a

Phenotype	Fish	Figures
Kupffer's vesicle morphology, abnormal	WT + MO1-rab11a	Fig. 3 from Westlake et al., 2011
melanosome transport decreased rate, abnormal	WT + MO1-rab11a	Fig. S3 from Westlake et al., 2011
vasculature malformed, abnormal	y1Tg + MO1-rab11a	Fig. 8 from Jopling et al., 2014

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Phenotype of all Fish created by or utilizing MO1-rab11a

Phenotype	Fish	Conditions	Figures
melanosome transport decreased rate, abnormal	WT + MO1-rab11a	standard conditions	Fig. S3 from Westlake et al., 2011
Kupffer's vesicle morphology, abnormal	WT + MO1-rab11a	standard conditions	Fig. 3 from Westlake et al., 2011
cell death increased occurrence, abnormal	WT + MO1-rab11a + MO2-rab11a	standard conditions	Fig. S4a from Kalén et al., 2009
head decreased size, abnormal	WT + MO1-rab11a + MO2-rab11a	standard conditions	Fig. S4a from Kalén et al., 2009
intersegmental vessel decreased functionality, abnormal	WT + MO1-rab11a + MO2-rab11a	standard conditions	Fig. S4a from Kalén et al., 2009

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Citations

Include unpublished citations

Aljiboury, A.A., Ingram, E., Krishnan, N., Ononiwu, F., Pal, D., Manikas, J., Taveras, C., Hall, N.A., Da Silva, J., Freshour, J., Hehnly, H. (2023) Rab8, Rab11, and Rab35 coordinate lumen and cilia formation during zebrafish left-right organizer development. PLoS Genetics. 19:e1010765e1010765
Jopling, H.M., Odell, A.F., Pellet-Many, C., Latham, A.M., Frankel, P., Sivaprasadarao, A., Walker, J.H., Zachary, I.C., Ponnambalam, S. (2014) Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine Kinase Regulates Endothelial Function and Blood Vessel Formation. Cells. 3:363-85
Tay, H.G., Schulze, S.K., Compagnon, J., Foley, F.C., Heisenberg, C.P., Yost, H.J., Abdelilah-Seyfried, S., and Amack, J.D. (2013) Lethal giant larvae 2 regulates development of the ciliated organ Kupffer's vesicle. Development (Cambridge, England). 140(7):1550-1559
Westlake, C.J., Baye, L.M., Nachury, M.V., Wright, K.J., Ervin, K.E., Phu, L., Chalouni, C., Beck, J.S., Kirkpatrick, D.S., Slusarski, D.C., Sheffield, V.C., Scheller, R.H., and Jackson, P.K. (2011) Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome. Proceedings of the National Academy of Sciences of the United States of America. 108(7):2759-2764
Kalén, M., Wallgard, E., Asker, N., Nasevicius, A., Athley, E., Billgren, E., Larson, J.D., Wadman, S.A., Norseng, E., Clark, K.J., He, L., Karlsson-Lindahl, L., Häger, A.K., Weber, H., Augustin, H., Samuelsson, T., Kemmet, C.K., Utesch, C.M., Essner, J.J., Hackett, P.B., and Hellström, M. (2009) Combination of reverse and chemical genetic screens reveals angiogenesis inhibitors and targets. Chemistry & Biology. 16(4):432-441

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