ZFIN Morpholino: MO2-spns2

Target Location

Genome Build: GRCz11Chromosome: 5

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-spns2

No data available

Phenotype

Phenotype resulting from MO2-spns2

Phenotype	Fish	Figures
embryonic heart tube morphogenesis disrupted, abnormal	AB/TU + MO2-spns2	Fig. 3 from Nakanaga et al., 2014
heart bifurcated, abnormal	ko07Tg + MO2-spns2	Fig. 2, Fig. 4 from Kawahara et al., 2009

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Phenotype of all Fish created by or utilizing MO2-spns2

Phenotype	Fish	Conditions	Figures
embryonic heart tube morphogenesis disrupted, abnormal	AB/TU + MO2-spns2	standard conditions	Fig. 3 from Nakanaga et al., 2014
heart bifurcated, abnormal	ko07Tg + MO2-spns2	standard conditions	Fig. 2, Fig. 4 from Kawahara et al., 2009
vasculature development disrupted, abnormal	y1Tg + MO2-s1pr1 + MO2-spns2	standard conditions	Fig. 7 from Mendelson et al., 2013
intersegmental vessel shortened, abnormal	y1Tg + MO2-s1pr1 + MO2-spns2	standard conditions	Fig. 7 from Mendelson et al., 2013

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Citations

Include unpublished citations

Fukui, H., Terai, K., Nakajima, H., Chiba, A., Fukuhara, S., Mochizuki, N. (2014) S1P-Yap1 Signaling Regulates Endoderm Formation Required for Cardiac Precursor Cell Migration in Zebrafish. Developmental Cell. 31:128-136
Nakanaga, K., Hama, K., Kano, K., Sato, T., Yukiura, H., Inoue, A., Saigusa, D., Tokuyama, H., Tomioka, Y., Nishina, H., Kawahara, A., and Aoki, J. (2014) Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo. Journal of biochemistry. 155(4):235-41
Hisano, Y., Ota, S., Takada, S., and Kawahara, A. (2013) Functional cooperation of spns2 and fibronectin in cardiac and lower jaw development. Biology Open. 2(8):789-794
Mendelson, K., Zygmunt, T., Torres-Vazquez, J., Evans, T., and Hla, T. (2013) Sphingosine-1-Phosphate Receptors S1pr1 and S1pr2 Cooperatively Regulate Embryonic Vascular Development. The Journal of biological chemistry. 288(4):2143-2156
Kawahara, A., Nishi, T., Hisano, Y., Fukui, H., Yamaguchi, A., and Mochizuki, N. (2009) The Sphingolipid Transporter Spns2 Functions in Migration of Zebrafish Myocardial Precursors. Science (New York, N.Y.). 323(5913):524-527

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