ZFIN Morpholino: MO2-osr1

Target Location

Genome Build: GRCz11Chromosome: 13

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-osr1

No data available

Phenotype

Phenotype resulting from MO2-osr1

Phenotype	Fish	Figures
anterior lateral mesoderm morphology, abnormal	AB/TU + MO2-osr1	Fig. 8 from Mudumana et al., 2008
anterior lateral plate mesoderm morphology, abnormal	AB/TU + MO2-osr1	Fig. 9 from Mudumana et al., 2008
caudal vein plexus dilated, abnormal	AB/TU + MO2-osr1	Fig. 7 from Mudumana et al., 2008
common cardinal vein increased diameter, abnormal	AB/TU + MO2-osr1	Fig. 7 from Mudumana et al., 2008
endoderm development disrupted, abnormal	AB/TU + MO2-osr1	Fig. 10 from Mudumana et al., 2008

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Phenotype of all Fish created by or utilizing MO2-osr1

Phenotype	Fish	Conditions	Figures
pronephric proximal convoluted tubule morphology, abnormal	AB/TU + MO2-osr1	standard conditions	Fig. 3 , Fig. 4 , Fig. 8 from Mudumana et al., 2008
intermediate mesodermal cell differentiation disrupted, abnormal	AB/TU + MO2-osr1	standard conditions	Fig. S4 from Mudumana et al., 2008
podocyte differentiation disrupted, abnormal	AB/TU + MO2-osr1	standard conditions	Fig. 5 from Tomar et al., 2014
presumptive endoderm increased width, abnormal	AB/TU + MO2-osr1	standard conditions	Fig. 10 from Mudumana et al., 2008
anterior lateral mesoderm morphology, abnormal	AB/TU + MO2-osr1	standard conditions	Fig. 8 from Mudumana et al., 2008

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Citations

Include unpublished citations

Drummond, B.E., Chambers, B.E., Wesselman, H.M., Gibson, S., Arceri, L., Ulrich, M.N., Gerlach, G.F., Kroeger, P.T., Leshchiner, I., Goessling, W., Wingert, R.A. (2022) osr1 Maintains Renal Progenitors and Regulates Podocyte Development by Promoting wnt2ba via the Antagonism of hand2. Biomedicines. 10(11):
Chou, C.W., Hsu, H.C., You, M.S., Lin, J., Liu, Y.W. (2016) The endoderm indirectly influences morphogenetic movements of the zebrafish head kidney through the posterior cardinal vein and VegfC. Scientific Reports. 6:30677
Terashima, A.V., Mudumana, S.P., Drummond, I.A. (2014) Odd skipped related 1 is a negative feedback regulator of Nodal-induced endoderm development. Developmental Dynamics : an official publication of the American Association of Anatomists. 243(12):1571-80
Tomar, R., Mudumana, S.P., Pathak, N., Hukreide, N.A., Drummond, I.A. (2014) osr1 Is Required for Podocyte Development Downstream of wt1a. Journal of the American Society of Nephrology : JASN. 25(11):2539-45
Neto, A., Mercader, N., and Gómez-Skarmeta, J.L. (2012) The osr1 and osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of wnt2b to maintain pectoral fin development. Development (Cambridge, England). 139(2):301-11
Mudumana, S.P., Hentschel, D., Liu, Y., Vasilyev, A., and Drummond, I.A. (2008) odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fate. Development (Cambridge, England). 135(20):3355-3367

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