ZFIN Morpholino: MO2-hand2

Target Location

Genome Build: GRCz11Chromosome: 1

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-hand2

No data available

Phenotype

Phenotype resulting from MO2-hand2

Phenotype	Fish	Figures
atrium decreased size, abnormal	AB + MO2-hand2	Fig. 4 from Maves et al., 2009
atrium shape, abnormal	AB + MO2-hand2	Fig. 4 from Maves et al., 2009
cardiac muscle cell organization quality, abnormal	WT + MO2-hand2	Fig. S7 from Hinits et al., 2012
cardiac muscle cell differentiation disrupted, abnormal	AB + MO2-hand2	Fig. 4 from Maves et al., 2009
cardiac ventricle decreased size, abnormal	AB + MO2-hand2	Fig. 4 from Maves et al., 2009

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Phenotype of all Fish created by or utilizing MO2-hand2

Phenotype	Fish	Conditions	Figures
heart morphogenesis process quality, abnormal	AB + MO2-hand2	standard conditions	Fig. 4 from Maves et al., 2009
cardiac muscle cell differentiation disrupted, abnormal	AB + MO2-hand2	standard conditions	Fig. 4 from Maves et al., 2009
cardiac ventricle shape, abnormal	AB + MO2-hand2	standard conditions	Fig. 4 from Maves et al., 2009
heart development disrupted, abnormal	AB + MO2-hand2	standard conditions	Fig. 4 from Maves et al., 2009
heart tube aplastic, abnormal	AB + MO2-hand2	standard conditions	Fig. 4 from Maves et al., 2009

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Citations

Include unpublished citations

Drummond, B.E., Chambers, B.E., Wesselman, H.M., Gibson, S., Arceri, L., Ulrich, M.N., Gerlach, G.F., Kroeger, P.T., Leshchiner, I., Goessling, W., Wingert, R.A. (2022) osr1 Maintains Renal Progenitors and Regulates Podocyte Development by Promoting wnt2ba via the Antagonism of hand2. Biomedicines. 10(11):
Prummel, K.D., Crowell, H.L., Nieuwenhuize, S., Brombacher, E.C., Daetwyler, S., Soneson, C., Kresoja-Rakic, J., Kocere, A., Ronner, M., Ernst, A., Labbaf, Z., Clouthier, D.E., Firulli, A.B., Sánchez-Iranzo, H., Naganathan, S.R., O'Rourke, R., Raz, E., Mercader, N., Burger, A., Felley-Bosco, E., Huisken, J., Robinson, M.D., Mosimann, C. (2022) Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma. Nature communications. 13:1677
Ando, K., Fukuhara, S., Izumi, N., Nakajima, H., Fukui, H., Kelsh, R.N., Mochizuki, N. (2016) Clarification of mural cell coverage of vascular endothelial cells by live imaging of zebrafish. Development (Cambridge, England). 143(8):1328-39
Perens, E.A., Garavito-Aguilar, Z.V., Guio-Vega, G.P., Peña, K.T., Schindler, Y.L., Yelon, D. (2016) Hand2 inhibits kidney specification while promoting vein formation within the posterior mesoderm. eLIFE. 5
Schupp, M.O., Waas, M., Chun, C.Z., Ramchandran, R. (2014) Transcriptional inhibition of etv2 expression is essential for embryonic cardiac development. Developmental Biology. 393(1):71-83
Nachtrab, G., Kikuchi, K., Tornini, V.A., and Poss, K.D. (2013) Transcriptional components of anteroposterior positional information during zebrafish fin regeneration. Development (Cambridge, England). 140(18):3754-3764
Hinits, Y., Pan, L., Walker, C., Dowd, J., Moens, C.B., and Hughes, S.M. (2012) Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation. Developmental Biology. 369(2):199-210
Zuniga, E., Rippen, M., Alexander, C., Schilling, T.F., and Crump, J.G. (2011) Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton. Development (Cambridge, England). 138(23):5147-5156
Maves, L., Tyler, A., Moens, C.B., and Tapscott, S.J. (2009) Pbx acts with Hand2 in early myocardial differentiation. Developmental Biology. 333(2):409-418
Reichenbach, B., Delalande, J.M., Kolmogorova, E., Prier, A., Nguyen, T., Smith, C.M., Holzschuh, J., and Shepherd, I.T. (2008) Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish. Developmental Biology. 318(1):52-64

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