ZFIN Morpholino: MO1-cdh5

Target Location

Genome Build: GRCz11Chromosome: 7

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-cdh5

No data available

Phenotype

Phenotype resulting from MO1-cdh5

Phenotype	Fish	Figures
blood circulation arrested, abnormal	zn1Tg + MO1-cdh5	Fig. 3 from Nicoli et al., 2007
blood circulation disrupted, abnormal	AB + MO1-cdh5	Fig. 2 from Mitchell et al., 2010
endocardial cushion morphology, abnormal	AB + MO1-cdh5	Fig. 7 from Chen et al., 2012
heart looping disrupted, abnormal	AB + MO1-cdh5	Fig. 2 from Mitchell et al., 2010
pericardium edematous, abnormal	AB + MO1-cdh5	Fig. 2 from Mitchell et al., 2010

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Phenotype of all Fish created by or utilizing MO1-cdh5

Phenotype	Fish	Conditions	Figures
blood circulation disrupted, abnormal	AB + MO1-cdh5	standard conditions	Fig. 2 from Mitchell et al., 2010
endocardial cushion morphology, abnormal	AB + MO1-cdh5	standard conditions	Fig. 7 from Chen et al., 2012
heart looping disrupted, abnormal	AB + MO1-cdh5	standard conditions	Fig. 2 from Mitchell et al., 2010
pericardium edematous, abnormal	AB + MO1-cdh5	standard conditions	Fig. 2 from Mitchell et al., 2010
pericardium increased size, abnormal	zn1Tg + MO1-cdh5	standard conditions	Fig. 3 from Nicoli et al., 2007

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Citations

Include unpublished citations

Klems, A., van Rijssel, J., Ramms, A.S., Wild, R., Hammer, J., Merkel, M., Derenbach, L., Préau, L., Hinkel, R., Suarez-Martinez, I., Schulte-Merker, S., Vidal, R., Sauer, S., Kivelä, R., Alitalo, K., Kupatt, C., van Buul, J.D., le Noble, F. (2020) The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models. Nature communications. 11:5319
Bornhorst, D., Xia, P., Nakajima, H., Dingare, C., Herzog, W., Lecaudey, V., Mochizuki, N., Heisenberg, C.P., Yelon, D., Abdelilah-Seyfried, S. (2019) Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions. Nature communications. 10:4113
Ni, R., Luo, L. (2018) A noncanonical function of histidyl-tRNA synthetase: inhibition of vascular hyperbranching during zebrafish development. FEBS Open Bio. 8:722-731
Sauteur, L., Affolter, M., Belting, H.G. (2017) Distinct and redundant functions of Esam and VE-cadherin during vascular morphogenesis. Development (Cambridge, England). 144(8):1554-1565
Lee, H.C., Lo, H.C., Lo, D.M., Su, M.Y., Hu, J.R., Wu, C.C., Chang, S.N., Dai, M.S., Tsai, C.T., Tsai, H.J. (2015) Amiodarone Induces Overexpression of Similar to Versican b to Repress the EGFR/Gsk3b/Snail Signaling Axis during Cardiac Valve Formation of Zebrafish Embryos. PLoS One. 10:e0144751
Chen, Y.H., Hsu, R.J., Chen, T.Y., Huang, Y.K., Lee, H.C., Hu, S.C., Harn, H.J., Jeng, J.R., Sun, C.K., Lin, S.Z., and Tsai, H.J. (2012) The toxic effect of Amiodarone on valve formation in the developing heart of zebrafish embryos. Reproductive toxicology (Elmsford, N.Y.). 33(2):233-244
Tobia, C., Chiodelli, P., Nicoli, S., Dell'era, P., Buraschi, S., Mitola, S., Foglia, E., van Loenen, P.B., Alewijnse, A.E., and Presta, M. (2012) Sphingosine-1-Phosphate Receptor-1 Controls Venous Endothelial Barrier Integrity in Zebrafish. Arterioscler. Thromb. Vasc. Biol.. 32(9):e104-116
Gjini, E., Hekking, L.H., Küchler, A., Saharinen, P., Wienholds, E., Post, J.A., Alitalo, K., and Schulte-Merker, S. (2011) Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity. Disease models & mechanisms. 4(1):57-66
Mitchell, I.C., Brown, T.S., Terada, L.S., Amatruda, J.F., and Nwariaku, F.E. (2010) Effect of Vascular Cadherin Knockdown on Zebrafish Vasculature during Development. PLoS One. 5(1):e8807
Nicoli, S., Ribatti, D., Cotelli, F., and Presta, M. (2007) Mammalian tumor xenografts induce neovascularization in zebrafish embryos. Cancer research. 67(7):2927-2931

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