ZFIN Morpholino: MO5-notch1a

Target Location

Genome Build: GRCz11Chromosome: 21

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO5-notch1a

No data available

Phenotype

Phenotype resulting from MO5-notch1a

Phenotype	Fish	Figures
dorsal aorta development process quality, abnormal	AB + MO5-notch1a	Fig. S4 from Kim et al., 2014
hematopoietic progenitor cell differentiation process quality, abnormal	AB + MO5-notch1a	Fig. S4 from Kim et al., 2014
hindbrain has extra parts of type Mauthner neuron, abnormal	ue1Tg; ue2Tg + MO5-notch1a	Fig. 1 from Almeida et al., 2018
spinal cord anterior region has extra parts of type Mauthner neuron axon, abnormal	ue1Tg; ue2Tg + MO5-notch1a	Fig. 1 from Almeida et al., 2018
vasculature development process quality, abnormal	AB + MO5-notch1a	Fig. S4 from Kim et al., 2014

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Phenotype of all Fish created by or utilizing MO5-notch1a

Phenotype	Fish	Conditions	Figures
hematopoietic progenitor cell differentiation process quality, abnormal	AB + MO5-notch1a	standard conditions	Fig. S4 from Kim et al., 2014
dorsal aorta development process quality, abnormal	AB + MO5-notch1a	standard conditions	Fig. S4 from Kim et al., 2014
vasculature development process quality, abnormal	AB + MO5-notch1a	standard conditions	Fig. S4 from Kim et al., 2014
hindbrain has extra parts of type Mauthner neuron, abnormal	ue1Tg; ue2Tg + MO5-notch1a	standard conditions	Fig. 1 from Almeida et al., 2018
spinal cord anterior region has extra parts of type Mauthner neuron axon, abnormal	ue1Tg; ue2Tg + MO5-notch1a	standard conditions	Fig. 1 from Almeida et al., 2018

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Citations

Include unpublished citations

Zhao, F., He, J., Tang, J., Cui, N., Shi, Y., Li, Z., Liu, S., Wang, Y., Ma, M., Zhao, C., Luo, L., Li, L. (2022) Brain milieu induces early microglial maturation through the BAX-Notch axis. Nature communications. 13:6117
Tie, R., Li, H., Cai, S., Liang, Z., Shan, W., Wang, B., Tan, Y., Zheng, W., Huang, H. (2019) Interleukin-6 signaling regulates hematopoietic stem cell emergence. Experimental & molecular medicine. 51:1-12
Almeida, R.G., Pan, S., Cole, K.L.H., Williamson, J.M., Early, J.J., Czopka, T., Klingseisen, A., Chan, J.R., Lyons, D.A. (2018) Myelination of Neuronal Cell Bodies when Myelin Supply Exceeds Axonal Demand. Current biology : CB. 28(8):1296-1305.e5
Chou, C.W., Lin, J., Jiang, Y.J., Liu, Y.W. (2017) Aberrant global and Jagged-mediated Notch signaling disrupts segregation between wt1-expressing and steroidogenic tissues in zebrafish. Endocrinology. 158(12):4206-4217
Butko, E., Distel, M., Pouget, C., Weijts, B., Kobayashi, I., Ng, K., Mosimann, C., Poulain, F.E., McPherson, A., Ni, C.W., Stachura, D.L., Del Cid, N., Espín-Palazón, R., Lawson, N.D., Dorsky, R., Clements, W.K., Traver, D. (2015) Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo. Development (Cambridge, England). 142:1050-61
Espín-Palazón, R., Stachura, D.L., Campbell, C.A., García-Moreno, D., Del Cid, N., Kim, A.D., Candel, S., Meseguer, J., Mulero, V., Traver, D. (2014) Proinflammatory signaling regulates hematopoietic stem cell emergence. Cell. 159:1070-85
Kim, A.D., Melick, C.H., Clements, W.K., Stachura, D.L., Distel, M., Panáková, D., MacRae, C., Mork, L.A., Crump, J.G., Traver, D. (2014) Discrete Notch signaling requirements in the specification of hematopoietic stem cells. The EMBO journal. 33(20):2363-73
Almeida, R.G., Czopka, T., Ffrench-Constant, C., and Lyons, D.A. (2011) Individual axons regulate the myelinating potential of single oligodendrocytes in vivo. Development (Cambridge, England). 138(20):4443-50
Ma, M., and Jiang, Y.J. (2007) Jagged2a-notch signaling mediates cell fate choice in the zebrafish pronephric duct. PLoS Genetics. 3(1):e18

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