ZFIN Morpholino: MO1-tcf7

Target Location

Genome Build: GRCz11Chromosome: 21

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-tcf7

No data available

Phenotype

Phenotype resulting from MO1-tcf7

Phenotype	Fish	Figures
brain wholly posteriorized, abnormal	WT + MO1-tcf7	Fig. 6 from Nyholm et al., 2007
cell population proliferation occurrence, abnormal	AB + MO1-tcf7	Fig. 3 from Bonner et al., 2008
midbrain morphology, abnormal	WT + MO1-tcf7	Fig. 6 from Nyholm et al., 2007
pectoral fin decreased size, abnormal	WT + MO1-tcf7	Fig. 3 from Nagayoshi et al., 2008
pectoral fin undulate, abnormal	WT + MO1-tcf7	Fig. 3 from Nagayoshi et al., 2008

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Phenotype of all Fish created by or utilizing MO1-tcf7

Phenotype	Fish	Conditions	Figures
cell population proliferation occurrence, abnormal	AB + MO1-tcf7	standard conditions	Fig. 3 from Bonner et al., 2008
pectoral fin decreased size, abnormal	WT + MO1-tcf7	standard conditions	Fig. 3 from Nagayoshi et al., 2008
brain wholly posteriorized, abnormal	WT + MO1-tcf7	standard conditions	Fig. 6 from Nyholm et al., 2007
pectoral fin undulate, abnormal	WT + MO1-tcf7	standard conditions	Fig. 3 from Nagayoshi et al., 2008
midbrain morphology, abnormal	WT + MO1-tcf7	standard conditions	Fig. 6 from Nyholm et al., 2007

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Citations

Include unpublished citations

Nicenboim, J., Malkinson, G., Lupo, T., Asaf, L., Sela, Y., Mayseless, O., Gibbs-Bar, L., Senderovich, N., Hashimshony, T., Shin, M., Jerafi-Vider, A., Avraham-Davidi, I., Krupalnik, V., Hofi, R., Almog, G., Astin, J.W., Golani, O., Ben-Dor, S., Crosier, P.S., Herzog, W., Lawson, N.D., Hanna, J.H., Yanai, I., Yaniv, K. (2015) Lymphatic vessels arise from specialized angioblasts within a venous niche. Nature. 522(7554):56-61
Zhu, P., Xu, X., Lin, X. (2015) Both ciliary and non-ciliary functions of Foxj1a confer Wnt/β-catenin signaling in zebrafish left-right patterning. Biology Open. 4(11):1376-86
Shimizu, N., Kawakami, K., and Ishitani, T. (2012) Visualization and exploration of Tcf/Lef function using a highly responsive Wnt/beta-catenin signaling-reporter transgenic zebrafish. Developmental Biology. 370(1):71-85
Aman, A., Nguyen, M., and Piotrowski, T. (2011) Wnt/β-catenin dependent cell proliferation underlies segmented lateral line morphogenesis. Developmental Biology. 349(2):470-482
McGraw, H.F., Drerup, C.M., Culbertson, M.D., Linbo, T., Raible, D.W., and Nechiporuk, A.V. (2011) Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium. Development (Cambridge, England). 138(18):3921-3930
Bonner, J., Gribble, S.L., Veien, E.S., Nikolaus, O.B., Weidinger, G., and Dorsky, R.I. (2008) Proliferation and patterning are mediated independently in the dorsal spinal cord downstream of canonical Wnt signaling. Developmental Biology. 313(1):398-407
Nagayoshi, S., Hayashi, E., Abe, G., Osato, N., Asakawa, K., Urasaki, A., Horikawa, K., Ikeo, K., Takeda, H., and Kawakami, K. (2008) Insertional mutagenesis by the Tol2 transposon-mediated enhancer trap approach generated mutations in two developmental genes: tcf7 and synembryn-like. Development (Cambridge, England). 135(1):159-169
Nyholm, M.K., Wu, S.F., Dorsky, R.I., and Grinblat, Y. (2007) The zebrafish zic2a-zic5 gene pair acts downstream of canonical Wnt signaling to control cell proliferation in the developing tectum. Development (Cambridge, England). 134(4):735-746

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