ZFIN Morpholino: MO2-dll4

Target Location

Genome Build: GRCz11Chromosome: 20

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-dll4

No data available

Phenotype

Phenotype resulting from MO2-dll4

Phenotype	Fish	Figures
angiogenesis disrupted, abnormal	WT + MO2-dll4	Fig. 3 from Villefranc et al., 2013
basal communicating artery increased size, abnormal	la116Tg + MO2-dll4	Fig. 4 from Rochon et al., 2015
CiD increased amount, abnormal	nns5Tg + MO2-dll4	Fig. 3 from Okigawa et al., 2014
intersegmental artery blood vessel endothelial cell increased amount, abnormal	y7Tg + MO2-dll4	Fig. S7 from Siekmann et al., 2007
intersegmental vessel has extra parts of type endothelial cell, abnormal	WT + MO2-dll4	Fig. 3 from Villefranc et al., 2013

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Phenotype of all Fish created by or utilizing MO2-dll4

Phenotype	Fish	Conditions	Figures
intersegmental vessel has extra parts of type endothelial cell, abnormal	WT + MO2-dll4	standard conditions	Fig. 3 from Villefranc et al., 2013
intersegmental vessel increased branchiness, abnormal	WT + MO2-dll4	standard conditions	Fig. 3 from Villefranc et al., 2013
angiogenesis disrupted, abnormal	WT + MO2-dll4	standard conditions	Fig. 3 from Villefranc et al., 2013
intersegmental vessel branchiness, ameliorated	la116Tg + MO2-dll4	chemical treatment by environment: SL-327	Fig. S5 from Shin et al., 2016
basal communicating artery increased size, abnormal	la116Tg + MO2-dll4	standard conditions	Fig. 4 from Rochon et al., 2015

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Citations

Include unpublished citations

Sahu, A., Devi, S., Jui, J., Goldman, D. (2021) Notch signaling via Hey1 and Id2b regulates Müller glia's regenerative response to retinal injury. Glia. 69(12):2882-2898
Taberner, L., Bañón, A., Alsina, B. (2020) Sensory Neuroblast Quiescence Depends on Vascular Cytoneme Contacts and Sensory Neuronal Differentiation Requires Initiation of Blood Flow. Cell Reports. 32:107903
Chen, X., Gays, D., Milia, C., Santoro, M.M. (2017) Cilia Control Vascular Mural Cell Recruitment in Vertebrates. Cell Reports. 18:1033-1047
Hasan, S.S., Tsaryk, R., Lange, M., Wisniewski, L., Moore, J.C., Lawson, N.D., Wojciechowska, K., Schnittler, H., Siekmann, A.F. (2017) Endothelial Notch signalling limits angiogenesis via control of artery formation. Nature cell biology. 19(8):928-940
Shin, M., Beane, T., Quillien, A., Male, I., Zhu, L.J., Lawson, N.D. (2016) Vegfa signals through ERK to promote angiogenesis, but not artery differentiation. Development (Cambridge, England). 143(20):3796-3805
Rochon, E.R., Wright, D.S., Schubert, M.M., Roman, B.L. (2015) Context-specific interactions between Notch and ALK1 cannot explain ALK1-associated arteriovenous malformations. Cardiovascular research. 107(1):143-52
Okigawa, S., Mizoguchi, T., Okano, M., Tanaka, H., Isoda, M., Jiang, Y.J., Suster, M., Higashijima, S.I., Kawakami, K., Itoh, M. (2014) Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a/V2b cell fate determination. Developmental Biology. 391(2):196-206
Quillien, A., Moore, J.C., Shin, M., Siekmann, A.F., Smith, T., Pan, L., Moens, C.B., Parsons, M.J., Lawson, N.D. (2014) Distinct Notch signaling outputs pattern the developing arterial system. Development (Cambridge, England). 141:1544-52
Villefranc, J.A., Nicoli, S., Bentley, K., Jeltsch, M., Zarkada, G., Moore, J.C., Gerhardt, H., Alitalo, K., and Lawson, N.D. (2013) A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development. Development (Cambridge, England). 140(7):1497-1506
Nicoli, S., Knyphausen, C.P., Zhu, L.J., Lakshmanan, A., and Lawson, N.D. (2012) miR-221 Is Required for Endothelial Tip Cell Behaviors during Vascular Development. Developmental Cell. 22(2):418-429

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