ZFIN Morpholino: MO2-foxc1a

Target Location

Genome Build: GRCz11Chromosome: 2

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-foxc1a

No data available

Phenotype

Phenotype resulting from MO2-foxc1a

Phenotype	Fish	Figures
blood circulation disrupted, abnormal	s843Tg; sd2Tg + MO2-foxc1a	Fig. 4 from De Val et al., 2008
brain hydrocephalic, abnormal	WT + MO2-foxc1a	Fig. 2 from Skarie et al., 2009
central nervous system hemorrhagic, abnormal	WT + MO2-foxc1a	Fig. 2 from Skarie et al., 2009
eye decreased size, abnormal	WT + MO2-foxc1a	Fig. 2 from Skarie et al., 2009
eye hemorrhagic, abnormal	WT + MO2-foxc1a	Fig. 2 from Skarie et al., 2009

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Phenotype of all Fish created by or utilizing MO2-foxc1a

Phenotype	Fish	Conditions	Figures
pronephric glomerulus lacks all parts of type pronephric glomerular capillary, abnormal	AB + MO2-foxc1a	standard conditions	Fig. 4 from He et al., 2014
pronephric podocyte cell projection malformed, abnormal	AB + MO2-foxc1a	standard conditions	Fig. 4 from He et al., 2014
podocyte development decreased process quality, abnormal	AB + MO2-foxc1a	standard conditions	Fig. 4 from He et al., 2014
pronephric glomerulus lacks all parts of type pronephric podocyte slit diaphragm, abnormal	AB + MO2-foxc1a	standard conditions	Fig. 4 from He et al., 2014
closure of optic fissure arrested, abnormal	WT + MO1-foxc1a + MO2-foxc1a	standard conditions	Fig. 6 from Lupo et al., 2011

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Citations

Include unpublished citations

Chrystal, P.W., French, C.R., Jean, F., Havrylov, S., van Baarle, S., Peturson, A.M., Xu, P., Crump, J.G., Pilgrim, D.B., Lehmann, O.J., Waskiewicz, A.J. (2021) The Axenfeld-Rieger Syndrome Gene FOXC1 Contributes to Left-Right Patterning. Genes. 12(2):
Umali, J., Hawkey-Noble, A., French, C.R. (2019) Loss of foxc1 in zebrafish reduces optic nerve size and cell number in the ganglion cell layer. Vision Research. 156:66-72
Jang, I.H., Lu, Y.F., Zhao, L., Wenzel, P.L., Kume, T., Datta, S.M., Arora, N., Guiu, J., Lagha, M., Kim, P.G., Do, E.K., Kim, J.H., Schlaeger, T.M., Zon, L.I., Bigas, A., Burns, C.E., Daley, G.Q. (2015) Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium. Blood. 125(9):1418-26
Li, J., Yue, Y., Dong, X., Jia, W., Li, K., Liang, D., Dong, Z., Wang, X., Nan, X., Zhang, Q., Zhao, Q. (2015) Zebrafish foxc1a plays a crucial role in early somitogenesis by restricting the expression of aldh1a2 directly. The Journal of biological chemistry. 290(16):10216-28
French, C.R., Seshadri, S., Destefano, A.L., Fornage, M., Arnold, C.R., Gage, P.J., Skarie, J.M., Dobyns, W.B., Millen, K.J., Liu, T., Dietz, W., Kume, T., Hofker, M., Emery, D.J., Childs, S.J., Waskiewicz, A.J., Lehmann, O.J. (2014) Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease. J. Clin. Invest.. 124(11):4877-81
He, B., Ebarasi, L., Zhao, Z., Guo, J., Ojala, J.R., Hultenby, K., De Val, S., Betsholtz, C., Tryggvason, K. (2014) Lmx1b and FoxC Combinatorially Regulate Podocin Expression in Podocytes. Journal of the American Society of Nephrology : JASN. 25(12):2764-77
Veldman, M.B., and Lin, S. (2012) Etsrp/Etv2 Is Directly Regulated by Foxc1a/b in the Zebrafish Angioblast. Circulation research. 110(2):220-229
Acharya, M., Huang, L., Fleisch, V.C., Allison, W.T., and Walter, M.A. (2011) A Complex Regulatory Network of Transcription Factors Critical for Ocular Development and Disease. Human molecular genetics. 20(8):1610-24
Lupo, G., Gestri, G., O'Brien, M., Denton, R.M., Chandraratna, R.A., Ley, S.V., Harris, W.A., and Wilson, S.W. (2011) Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme. Proceedings of the National Academy of Sciences of the United States of America. 108(21):8698-8703
Lee, H.C., Tseng, W.A., Lo, F.Y., Liu, T.M., and Tsai, H.J. (2009) FoxD5 mediates anterior-posterior polarity through upstream modulator Fgf signaling during zebrafish somitogenesis. Developmental Biology. 336(2):232-245

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