ZFIN Morpholino: MO1-ccm2

Target Location

Genome Build: GRCz11Chromosome: 20

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-ccm2

No data available

Phenotype

Phenotype resulting from MO1-ccm2

Phenotype	Fish	Figures
blood vasculature obstructed, abnormal	y1Tg + MO1-ccm2	Fig. 4 from Kleaveland et al., 2009
blood vessel endothelial cell cell-cell junction decreased length, abnormal	WT + MO1-ccm2	Fig. S8 from Kleaveland et al., 2009
heart dilated, abnormal	twu34Tg + MO1-ccm2	Figure 5 from Yang et al., 2023 Figure 3 - figure supplement 1 from Li et al., 2021 Fig. S5 from Choi et al., 2018 Fig. 2 from Zheng et al., 2010 Fig. 4 from Kleaveland et al., 2009
heart edematous, abnormal	y1Tg + MO1-ccm2	Fig. 4 from Kleaveland et al., 2009

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Phenotype of all Fish created by or utilizing MO1-ccm2

Phenotype	Fish	Conditions	Figures
blood vessel endothelial cell cell-cell junction decreased length, abnormal	WT + MO1-ccm2	standard conditions	Fig. S8 from Kleaveland et al., 2009
heart dilated, abnormal	p150Tg + MO1-ccm2	standard conditions	Fig. 2 from Zheng et al., 2010
heart dilated, abnormal	twu34Tg + MO1-ccm2	standard conditions	Figure 5 from Yang et al., 2023 Fig. S5 from Choi et al., 2018
heart dilated, abnormal	y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 + MO1-ccm2	standard conditions	Figure 6 from Li et al., 2021
caudal vein plexus dilated, abnormal	y1Tg + CRISPR1-ccm2 + CRISPR2-ccm2 + CRISPR3-ccm2 + CRISPR4-ccm2 + MO1-ccm2	standard conditions	Figure 6 from Li et al., 2021

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Citations

Include unpublished citations

Li, W., McCurdy, S., Lopez-Ramirez, M.A., Lee, H.S., Ginsberg, M.H. (2025) Genetic inactivation of the β1 adrenergic receptor prevents cerebral cavernous malformations in zebrafish. eLIFE. 13:
Yang, X., Wu, S.T., Gao, R., Wang, R., Wang, Y., Dong, Z., Wang, L., Qi, C., Wang, X., Schmitz, M.L., Liu, R., Han, Z., Wang, L., Zheng, X. (2023) Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers Cerebral cavernous malformation. JCI insight. 8(5):
Li, W., Tran, V., Shaked, I., Xue, B., Moore, T., Lightle, R., Kleinfeld, D., Awad, I.A., Ginsberg, M.H. (2021) Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations. eLIFE. 10:
Choi, J.P., Wang, R., Yang, X., Wang, X., Wang, L., Ting, K.K., Foley, M., Cogger, V., Yang, Z., Liu, F., Han, Z., Liu, R., Baell, J., Zheng, X. (2018) Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations. Science advances. 4:eaau0731
Rosen, J.N., Sogah, V.M., Ye, L.Y., and Mably, J.D. (2013) Ccm2-like is required for cardiovascular development as a novel component of the Heg-CCM pathway. Developmental Biology. 376(1):74-85
Zheng, X., Xu, C., Di Lorenzo, A., Kleaveland, B., Zou, Z., Seiler, C., Chen, M., Cheng, L., Xiao, J., He, J., Pack, M.A., Sessa, W.C., and Kahn, M.L. (2010) CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. J. Clin. Invest.. 120(8):2795-2804
Kleaveland, B., Zheng, X., Liu, J.J., Blum, Y., Tung, J.J., Zou, Z., Chen, M., Guo, L., Lu, M.M., Zhou, D., Kitajewski, J., Affolter, M., Ginsberg, M.H., and Kahn, M.L. (2009) Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nature medicine. 15(2):169-176
Mably, J.D., Chuang, L.P., Serluca, F.C., Mohideen, M.A., Chen, J.N., and Fishman, M.C. (2006) santa and valentine pattern concentric growth of cardiac myocardium in the zebrafish. Development (Cambridge, England). 133(16):3139-3146

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