ZFIN Morpholino: MO1-tcf7l1a

Target Location

Genome Build: GRCz11Chromosome: 10

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-tcf7l1a

No data available

Phenotype

Phenotype resulting from MO1-tcf7l1a

Phenotype	Fish	Figures
atrium has extra parts of type cardiac muscle cell, abnormal	f2Tg + MO1-tcf7l1a + MO4-tp53	Fig. 1 from Sorrell et al., 2013
axial mesodermal cell fate specification increased occurrence, abnormal	ml1Tg/ml1Tg + MO1-tcf7l1a	Figure 2 from Johansson et al., 2019
axis distended, abnormal	ml1Tg/ml1Tg + MO1-tcf7l1a	Figure 2 from Johansson et al., 2019
cardiac ventricle has extra parts of type cardiac muscle cell, abnormal	f2Tg + MO1-tcf7l1a + MO4-tp53	Fig. 1 from Sorrell et al., 2013
eye aplastic, abnormal	AB + MO1-tcf7l1a	Fig. 1 from Domené et al., 2008 Fig. 3 from Dorsky et al., 2003 Fig. 2 from Dorsky et al., 2002

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Phenotype of all Fish created by or utilizing MO1-tcf7l1a

Phenotype	Fish	Conditions	Figures
axis distended, abnormal	ml1Tg/ml1Tg + MO1-tcf7l1a	control	Figure 2 from Johansson et al., 2019
axial mesodermal cell fate specification increased occurrence, abnormal	ml1Tg/ml1Tg + MO1-tcf7l1a	control	Figure 2 from Johansson et al., 2019
eye aplastic, abnormal	AB + MO1-tcf7l1a	standard conditions	Fig. 1 from Domené et al., 2008
head anterior region truncated, abnormal	WT + MO1-tcf7l1a	standard conditions	Fig. 3 from Kagermeier-Schenk et al., 2011
eye hypoplastic, abnormal	WT + MO1-tcf7l1a	standard conditions	Fig. 3 from Kagermeier-Schenk et al., 2011

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Citations

Include unpublished citations

Coppola, U., Saha, B., Kenney, J., Waxman, J.S. (2024) A Foxf1-Wnt-Nr2f1 cascade promotes atrial cardiomyocyte differentiation in zebrafish. PLoS Genetics. 20:e1011222e1011222
He, M., Zhang, R., Jiao, S., Zhang, F., Ye, D., Wang, H., Sun, Y. (2020) Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors. PLoS Biology. 18:e3000561
Johansson, M., Giger, F.A., Fielding, T., Houart, C. (2019) Dkk1 Controls Cell-Cell Interaction through Regulation of Non-nuclear β-Catenin Pools. Developmental Cell. 51(6):775-786.e3
Mandal, A., Holowiecki, A., Song, Y.C., Waxman, J.S. (2017) Wnt signaling balances specification of the cardiac and pharyngeal muscle fields. Mechanisms of Development. 143:32-41
Lu, F.I., Sun, Y.H., Wei, C.Y., Thisse, C., Thisse, B. (2014) Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/β-catenin pathway. Nature communications. 5:5368
Sorrell, M.R., Dohn, T.E., D'Aniello, E., and Waxman, J.S. (2013) Tcf7l1 proteins cell autonomously restrict cardiomyocyte and promote endothelial specification in zebrafish. Developmental Biology. 380(2):199-210
Shimizu, N., Kawakami, K., and Ishitani, T. (2012) Visualization and exploration of Tcf/Lef function using a highly responsive Wnt/beta-catenin signaling-reporter transgenic zebrafish. Developmental Biology. 370(1):71-85
Kagermeier-Schenk, B., Wehner, D., Ozhan-Kizil, G., Yamamoto, H., Li, J., Kirchner, K., Hoffmann, C., Stern, P., Kikuchi, A., Schambony, A., and Weidinger, G. (2011) Waif1/5T4 Inhibits Wnt/β-Catenin Signaling and Activates Noncanonical Wnt Pathways by Modifying LRP6 Subcellular Localization. Developmental Cell. 21(6):1129-43
Faro, A., Boj, S.F., Ambrósio, R., van den Broek, O., Korving, J., and Clevers, H. (2009) T-Cell Factor 4 (tcf7l2) Is the Main Effector of Wnt Signaling During Zebrafish Intestine Organogenesis. Zebrafish. 6(1):59-68
Gribble, S.L., Kim, H.S., Bonner, J., Wang, X., and Dorsky, R.I. (2009) Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression. Development (Cambridge, England). 136(5):781-789

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