ZFIN Morpholino: MO1-gata5

Target Location

Genome Build: GRCz11Chromosome: 23

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-gata5

No data available

Phenotype

Phenotype resulting from MO1-gata5

Phenotype	Fish	Figures
anterior lateral plate mesoderm nkx2.5 expression decreased amount, abnormal	WT + MO1-gata5	Fig. 4 from Wen et al., 2017
anterior lateral plate mesoderm myocardial precursor myh7 expression decreased amount, abnormal	WT + MO1-gata5	Fig. 4 from Wen et al., 2017
anterior lateral plate mesoderm myocardial precursor myl7 expression decreased amount, abnormal	WT + MO1-gata5	Fig. 4 from Wen et al., 2017
embryonic heart tube development disrupted, abnormal	WT + MO1-gata5	Fig. 4 , Fig. 5 from Peterkin et al., 2007
heart bifurcated, abnormal	knu9Tg + MO1-gata5 (AB)	Fig. 6 from Park et al., 2009 Fig. 1 from Holtzinger et al., 2007

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Phenotype of all Fish created by or utilizing MO1-gata5

Phenotype	Fish	Conditions	Figures
heart rudiment morphology, abnormal	WT + MO1-gata5	standard conditions	Fig. 2 from Hempel et al., 2017
heart physical object quality, abnormal	WT + MO1-gata5	standard conditions	Fig. 1 from Holtzinger et al., 2007
heart cardiac muscle cell decreased amount, abnormal	WT + MO1-gata5	standard conditions	Fig. 5 from Jia et al., 2007
anterior lateral plate mesoderm nkx2.5 expression decreased amount, abnormal	WT + MO1-gata5	standard conditions	Fig. 4 from Wen et al., 2017
heart tube malformed, abnormal	WT + MO1-gata5	standard conditions	Fig. 4 , Fig. 5 from Peterkin et al., 2007

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Citations

Include unpublished citations

Song, M., Yuan, X., Racioppi, C., Leslie, M., Stutt, N., Aleksandrova, A., Christiaen, L., Wilson, M.D., Scott, I.C. (2022) GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate. Science advances. 8:eabg0834
Jia, W., Liang, D., Li, N., Liu, M., Dong, Z., Li, J., Dong, X., Yue, Y., Hu, P., Yao, J., Zhao, Q. (2018) Zebrafish microRNA miR-210-5p inhibits primitive myelopoiesis by silencing foxj1b and slc3a2a mRNAs downstream of gata4/5/6 transcription factor genes. The Journal of biological chemistry. 294(8):2732-2743
Yuan, X., Song, M., Devine, P., Bruneau, B.G., Scott, I.C., Wilson, M.D. (2018) Heart enhancers with deeply conserved regulatory activity are established early in zebrafish development. Nature communications. 9:4977
Hempel, M., Casar Tena, T., Diehl, T., Burczyk, M.S., Strom, T.M., Kubisch, C., Philipp, M., Lessel, D. (2017) Compound heterozygous GATA5 mutations in a girl with hydrops fetalis, congenital heart defects and genital anomalies. Human genetics. 136(3):339-346
Wen, B., Yuan, H., Liu, X., Wang, H., Chen, S., Chen, Z., de The, H., Zhou, J., Zhu, J. (2017) GATA5 SUMOylation is indispensable for zebrafish cardiac development. Biochimica et biophysica acta. 1861(7):1691-1701
Lin, C.Y., Huang, C.C., Wang, W.D., Hsiao, C.D., Cheng, C.F., Wu, Y.T., Lu, Y.F., and Hwang, S.P. (2013) Low temperature mitigates cardia bifida in zebrafish embryos. PLoS One. 8(7):e69788
Liang, D., Jia, W., Li, J., Li, K., and Zhao, Q. (2012) Retinoic Acid signaling plays a restrictive role in zebrafish primitive myelopoiesis. PLoS One. 7(2):e30865
Lou, X., Deshwar, A.R., Crump, J.G., and Scott, I.C. (2011) Smarcd3b and Gata5 promote a cardiac progenitor fate in the zebrafish embryo. Development (Cambridge, England). 138(15):3113-23
Park, J.S., Kim, H.S., Kim, J.D., Seo, J., Chung, K.S., Lee, H.S., Huh, T.L., Jo, I., and Kim, Y.O. (2009) Isolation of a ventricle-specific promoter for the zebrafish ventricular myosin heavy chain (vmhc) gene and its regulation by GATA factors during embryonic heart development. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(6):1574-1581
Peterkin, T., Gibson, A., and Patient, R. (2009) Common genetic control of haemangioblast and cardiac development in zebrafish. Development (Cambridge, England). 136(9):1465-1474

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