ZFIN Morpholino: MO1-flt4

Target Location

Genome Build: GRCz11Chromosome: 14

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-flt4

No data available

Phenotype

Phenotype resulting from MO1-flt4

Phenotype	Fish	Figures
angiogenesis disrupted, abnormal	y1Tg/y1Tg + MO1-flt4	Fig. 7 from Gore et al., 2011
intersegmental artery blood vessel endothelial cell decreased amount, abnormal	y7Tg + MO1-flt4	Fig. 3 from Siekmann et al., 2007
intersegmental vessel absent, abnormal	y1Tg/y1Tg + MO1-flt4	Fig. 7 from Gore et al., 2011
intersegmental vessel blood vessel endothelial cell decreased amount, abnormal	y7Tg + MO1-flt4	Fig. S5 from Siekmann et al., 2007
motor neuron axon guidance process quality, abnormal	ml2Tg; ncv1Tg + MO1-flt4	Fig. 6 from Kwon et al., 2013

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Phenotype of all Fish created by or utilizing MO1-flt4

Phenotype	Fish	Conditions	Figures
intersegmental vessel absent, abnormal	y1Tg/y1Tg + MO1-flt4	standard conditions	Fig. 7 from Gore et al., 2011
angiogenesis disrupted, abnormal	y1Tg/y1Tg + MO1-flt4	standard conditions	Fig. 7 from Gore et al., 2011
venous blood vessel morphogenesis disrupted, abnormal	WT + MO1-flt4	standard conditions	Fig. 3 from Herbert et al., 2009
selective angioblast sprouting disrupted, abnormal	WT + MO1-flt4	standard conditions	Fig. 3 from Herbert et al., 2009
intersegmental vessel blood vessel endothelial cell decreased amount, abnormal	y7Tg + MO1-flt4	standard conditions	Fig. S5 from Siekmann et al., 2007

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Citations

Include unpublished citations

Chou, C.W., Hsu, H.C., You, M.S., Lin, J., Liu, Y.W. (2016) The endoderm indirectly influences morphogenetic movements of the zebrafish head kidney through the posterior cardinal vein and VegfC. Scientific Reports. 6:30677
Baeyens, N., Nicoli, S., Coon, B.G., Ross, T.D., Van den Dries, K., Han, J., Lauridsen, H.M., Mejean, C.O., Eichmann, A., Thomas, J.L., Humphrey, J.D., Schwartz, M.A. (2015) Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point. eLIFE. 4
Yokota, Y., Nakajima, H., Wakayama, Y., Muto, A., Kawakami, K., Fukuhara, S., Mochizuki, N. (2015) Endothelial Ca(2+) oscillations reflect VEGFR signaling-regulated angiogenic capacity in vivo. eLIFE. 4
Kwon, H.B., Fukuhara, S., Asakawa, K., Ando, K., Kashiwada, T., Kawakami, K., Hibi, M., Kwon, Y.G., Kim, K.W., Alitalo, K., and Mochizuki, N. (2013) The parallel growth of motoneuron axons with the dorsal aorta depends on Vegfc/Vegfr3 signaling in zebrafish. Development (Cambridge, England). 140(19):4081-4090
Herbert, S.P., Cheung, J.Y., and Stainier, D.Y. (2012) Determination of Endothelial Stalk versus Tip Cell Potential during Angiogenesis by H2.0-like Homeobox-1. Current biology : CB. 22(19):1789-1794
Nicoli, S., Knyphausen, C.P., Zhu, L.J., Lakshmanan, A., and Lawson, N.D. (2012) miR-221 Is Required for Endothelial Tip Cell Behaviors during Vascular Development. Developmental Cell. 22(2):418-429
Gore, A.V., Swift, M.R., Cha, Y.R., Lo, B., McKinney, M.C., Li, W., Castranova, D., Davis, A., Mukouyama, Y.S., and Weinstein, B.M. (2011) Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3. Development (Cambridge, England). 138(22):4875-4886
Fukui, H., Hanaoka, R., and Kawahara, A. (2009) Noncanonical Activity of Seryl-tRNA Synthetase Is Involved in Vascular Development. Circulation research. 104(11):1253-1259
Herbert, S.P., Huisken, J., Kim, T.N., Feldman, M.E., Houseman, B.T., Wang, R.A., Shokat, K.M., and Stainier, D.Y. (2009) Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science (New York, N.Y.). 326(5950):294-298
Siekmann, A.F., and Lawson, N.D. (2007) Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries. Nature. 445(7129):781-784

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