ZFIN Morpholino: MO3-ascl1a

Target Location

Genome Build: GRCz11Chromosome: 4

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO3-ascl1a

No data available

Phenotype

Phenotype resulting from MO3-ascl1a

Phenotype	Fish	Figures
sympathetic ganglion development disrupted, abnormal	WT + MO3-ascl1a	Fig. 7 from Pei et al., 2013

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Phenotype of all Fish created by or utilizing MO3-ascl1a

Phenotype	Fish	Conditions	Figures
regenerating tissue retina zic2b expression decreased amount, abnormal	WT + MO3-ascl1a	perforation: retina	Fig. 5 from Kaur et al., 2018
regenerating tissue retina foxn4 expression decreased amount, abnormal	WT + MO3-ascl1a	perforation: retina	Fig. 6 from Kaur et al., 2018
regenerating tissue retina mmp9 expression increased amount, abnormal	WT + MO3-ascl1a	perforation: retina, chemical treatment: DAPT	Fig. 4 from Kaur et al., 2018
regenerating tissue retina ascl1a expression increased amount, abnormal	WT + MO3-ascl1a	perforation: retina, chemical treatment: DAPT	Fig. 4 from Kaur et al., 2018
regenerating tissue retina mmp9 expression increased amount, abnormal	WT + MO3-ascl1a	perforation: retina	Fig. 4 from Kaur et al., 2018

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Citations

Include unpublished citations

Kaur, S., Gupta, S., Chaudhary, M., Khursheed, M.A., Mitra, S., Kurup, A.J., Ramachandran, R. (2018) let-7 MicroRNA-Mediated Regulation of Shh Signaling and the Gene Regulatory Network Is Essential for Retina Regeneration. Cell Reports. 23:1409-1423
Pei, D., Luther, W., Wang, W., Paw, B.H., Stewart, R.A., and George, R.E. (2013) Distinct Neuroblastoma-associated Alterations of PHOX2B Impair Sympathetic Neuronal Differentiation in Zebrafish Models. PLoS Genetics. 9(6):e1003533
Gerety, S.S., and Wilkinson, D.G. (2011) Morpholino artifacts provide pitfalls and reveal a novel role for pro-apoptotic genes in hindbrain boundary development. Developmental Biology. 350(2):279-289
Nikolaou, N., Watanabe-Asaka, T., Gerety, S., Distel, M., Köster, R.W., and Wilkinson, D.G. (2009) Lunatic fringe promotes the lateral inhibition of neurogenesis. Development (Cambridge, England). 136(15):2523-2533
Sarrazin, A.F., Villablanca, E.J., Nunez, V.A., Sandoval, P.C., Ghysen, A., and Allende, M.L. (2006) Proneural gene requirement for hair cell differentiation in the zebrafish lateral line. Developmental Biology. 295(2):534-545
Amoyel, M., Cheng, Y.C., Jiang, Y.J., and Wilkinson, D.G. (2005) Wnt1 regulates neurogenesis and mediates lateral inhibition of boundary cell specification in the zebrafish hindbrain. Development (Cambridge, England). 132(4):775-785

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