ZFIN Morpholino: MO1-tcf7l1b

Target Location

Genome Build: GRCz11Chromosome: 8

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-tcf7l1b

No data available

Phenotype

Phenotype resulting from MO1-tcf7l1b

Phenotype	Fish	Figures
atrium has extra parts of type cardiac muscle cell, abnormal	f2Tg + MO1-tcf7l1b + MO4-tp53	Fig. 1 from Sorrell et al., 2013
axon guidance disrupted, abnormal	AB + MO1-tcf7l1b	Fig. 3 from Riley et al., 2004
brain decreased size, abnormal	WT + MO1-tcf7l1b	Fig. 3 from Dorsky et al., 2003
cardiac ventricle has extra parts of type cardiac muscle cell, abnormal	f2Tg + MO1-tcf7l1b + MO4-tp53	Fig. 1 from Sorrell et al., 2013
cell proliferation in hindbrain disrupted, abnormal	WT + MO1-tcf7l1b	Fig. 4 from Amoyel et al., 2005

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Phenotype of all Fish created by or utilizing MO1-tcf7l1b

Phenotype	Fish	Conditions	Figures
hindbrain commissure neuron absent, abnormal	AB + MO1-tcf7l1b	standard conditions	Fig. 3 from Riley et al., 2004
rhombomere primary neuron disorganized, abnormal	AB + MO1-tcf7l1b	standard conditions	Fig. 3 from Riley et al., 2004
rhombomere primary neuron crowded, abnormal	AB + MO1-tcf7l1b	standard conditions	Fig. 3 from Riley et al., 2004
Mauthner neuron axon decreased length, abnormal	AB + MO1-tcf7l1b	standard conditions	Fig. 3 from Riley et al., 2004
radial glial cell cell projection irregular spatial pattern, abnormal	AB + MO1-tcf7l1b	standard conditions	Fig. 3 from Riley et al., 2004

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Citations

Include unpublished citations

Mandal, A., Holowiecki, A., Song, Y.C., Waxman, J.S. (2017) Wnt signaling balances specification of the cardiac and pharyngeal muscle fields. Mechanisms of Development. 143:32-41
Lu, F.I., Sun, Y.H., Wei, C.Y., Thisse, C., Thisse, B. (2014) Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/β-catenin pathway. Nature communications. 5:5368
Sorrell, M.R., Dohn, T.E., D'Aniello, E., and Waxman, J.S. (2013) Tcf7l1 proteins cell autonomously restrict cardiomyocyte and promote endothelial specification in zebrafish. Developmental Biology. 380(2):199-210
Gerety, S.S., and Wilkinson, D.G. (2011) Morpholino artifacts provide pitfalls and reveal a novel role for pro-apoptotic genes in hindbrain boundary development. Developmental Biology. 350(2):279-289
Ro, H., and Dawid, I.B. (2011) Modulation of Tcf3 repressor complex composition regulates cdx4 expression in zebrafish. The EMBO journal. 30(14):2894-907
Gribble, S.L., Kim, H.S., Bonner, J., Wang, X., and Dorsky, R.I. (2009) Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression. Development (Cambridge, England). 136(5):781-789
Caneparo, L., Huang, Y.L., Staudt, N., Tada, M., Ahrendt, R., Kazanskaya, O., Niehrs, C., and Houart, C. (2007) Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/betacatenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek. Genes & Development. 21(4):465-480
Nyholm, M.K., Wu, S.F., Dorsky, R.I., and Grinblat, Y. (2007) The zebrafish zic2a-zic5 gene pair acts downstream of canonical Wnt signaling to control cell proliferation in the developing tectum. Development (Cambridge, England). 134(4):735-746
Amoyel, M., Cheng, Y.C., Jiang, Y.J., and Wilkinson, D.G. (2005) Wnt1 regulates neurogenesis and mediates lateral inhibition of boundary cell specification in the zebrafish hindbrain. Development (Cambridge, England). 132(4):775-785
Riley, B.B., Chiang, M.Y., Storch, E.M., Heck, R., Buckles, G.R., and Lekven, A.C. (2004) Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain. Developmental Dynamics : an official publication of the American Association of Anatomists. 231(2):278-291

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