miRNA Gene
mir1-2
- ID
- ZDB-MIRNAG-081205-6
- Name
- microRNA 1-2
- Symbol
- mir1-2 Nomenclature History
- Previous Names
- Type
- miRNA_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- None
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| zf2097 | unknown | Unknown | Unknown | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-mir1-1,mir1-2 | N/A | (4) |
| MO2-mir1-1,mir1-2 | N/A | (3) |
| MO3-mir1-1,mir1-2 | N/A | (3) |
| TALEN1-mir1-2 | Liu et al., 2013 |
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Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mir1-2-201
(1)
|
Ensembl | 87 nt | ||
| miRNA | mir1-001 (1) | 22 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(mir1-2:DsRed) |
|
| 1 | Liu et al., 2013 | |
| Tg(mir1-2_MA:DsRed) |
|
| 1 | Liu et al., 2013 | |
| Tg(mir1-2_MB:DsRed) |
|
| 1 | Liu et al., 2013 |
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| Relationship | Marker Type | Marker | Citations |
|---|---|---|---|
| Contained in | PAC | BUSM1-SL11 |
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No data available
- Martín, L., Kamstra, J.H., Hurem, S., Lindeman, L.C., Brede, D.A., Aanes, H., Babiak, I., Arenal, A., Oughton, D., Salbu, B., Lyche, J.L., Aleström, P. (2021) Altered non-coding RNA expression profile in F1 progeny 1 year after parental irradiation is linked to adverse effects in zebrafish. Scientific Reports. 11:4142
- Romano, N., Ceci, M. (2020) Are microRNAs responsible for cardiac hypertrophy in fish and mammals? What we can learn in the activation process in a zebrafish ex vivo model. Biochimica et biophysica acta. Molecular basis of disease. 1866(11):165896
- Desvignes, T., Batzel, P., Sydes, J., Eames, B.F., Postlethwait, J.H. (2019) miRNA analysis with Prost! reveals evolutionary conservation of organ-enriched expression and post-transcriptional modifications in three-spined stickleback and zebrafish. Scientific Reports. 9:3913
- Ceci, M., Carlantoni, C., Missinato, M.A., Bonvissuto, D., Di Giacomo, B., Contu, R., Romano, N. (2018) Micro RNAs are involved in activation of epicardium during zebrafish heart regeneration. Cell death discovery. 4:41
- Nachtigall, P., Dias, M., Pinhal, D. (2014) Evolution and genomic organization of muscle microRNAs in fish genomes. BMC Evolutionary Biology. 14:196
- Lin, C.Y., Lee, H.C., Fu, C.Y., Ding, Y.Y., Chen, J.S., Lee, M.H., Huang, W.J., and Tsai, H.J. (2013) miR-1 and miR-206 target different genes to have opposing roles during angiogenesis in zebrafish embryos. Nature communications. 4:2829
- Liu, Y., Luo, D., Zhao, H., Zhu, Z., Hu, W., and Cheng, C.H. (2013) Inheritable and Precise Large Genomic Deletions of Non-Coding RNA Genes in Zebrafish Using TALENs. PLoS One. 8(10):e76387
- Mishima, Y., Fukao, A., Kishimoto, T., Sakamoto, H., Fujiwara, T., and Inoue, K. (2012) Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 109(4):1104-1109
- Yin, V.P., Lepilina, A., Smith, A., and Poss, K.D. (2012) Regulation of zebrafish heart regeneration by miR-133. Developmental Biology. 365(2):319-327
- Mallappa, C., Nasipak, B.T., Etheridge, L., Androphy, E.J., Jones, S.N., Sagerström, C.G., Ohkawa, Y., and Imbalzano, A.N. (2010) Myogenic microRNA expression requires ATP-dependent chromatin remodeling enzyme function. Molecular and cellular biology. 30(13):3176-3186
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