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Figure 6

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Publication: Dahlgren et al., 2026 - ER-associated degradation pathway protein SEL1L plays an evolutionarily conserved role in platelet adhesion
All Figures: Figures for Dahlgren et al., 2026

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Figure 6 Reduced adherence to collagen in Mx1-cre Sel1l^fl/fl platelets under flow.

(A) Representative images of murine platelets (green) adhering to a collagen-coated chamber after perfusion of whole blood from both a control Mx1-cre^–Sel1l^fl/fl and a knockdown Mx1-cre⁺ Sel1l^fl/fl mouse. Scale bars: 10 μm. (B) Quantification of the change in MFI between the beginning and end of the whole blood perfusion across collagen was normalized to the control for each pair. n = 6 cre⁺/cre^– sibling pairs. *P < 0.05 by Wilcoxon’s matched-pairs signed-rank test; a significant decrease in MFI change was found between control and knockdown groups.

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