FIGURE 1

FIGURE 1

The alignments of the protein sequences of Rs1a (NP_001003438.1) and Rs1b (NP_001004655.1) with human orthologue RS1 (hRS1 (NP_000321.1)) show a high degree of homology between the three proteins. The alignment was performed using the multiple sequence alignment program Clustal Omega (version 1.2.2.) using default parameters. Rs1a and Rs1b have a similarity score to each other of 72.5% and to hRS1, respectively, 81.7% and 71.5%. Amino acids with identical physiochemical properties are taken into account for the determination of similarity. (*) denotes identical residues, conversed residues are indicated with (:), and similar residues with (.). RS1 = retinoschisin. In the sequence of hRS1, the protein's domains are indicated. Red = N‐terminal signal peptide and C‐terminal segment, orange = RS domain, green = discoidin domain.