ZFIN Image: Konar et al., 2025, FIGURE 5

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Figure Caption

FIGURE 5

Differentially expressed SASP factors in genetic mutants with chronic photoreceptor damage. Bulk RNAseq was performed on whole zebrafish retinas from bbs2^−/− and cep290^−/− ciliopathy mutants. (A, B) Volcano plots of differentially expressed SASP factors in bbs2^−/−or cep290^−/− mutants at 6 mpf. Dashed lines represent values with a |log₂FC| > 2 and p-values <10⁻⁶. Top significantly upregulated factors are labeled for each time point. (C) Heatmap showing differentially expressed SASP factors with a log₂FC > 1.5 and p-values <10⁻⁶ in the indicated mutants; bolded genes are part of the overlapping set of SRRFs.

Acknowledgments

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