FIGURE 3

FIGURE 3

Gene Ontology (GO) analysis of differentially expressed SASP factors after light and NMDA damage. (A) GO analysis of the molecular function of the most enriched SASP factors in light damaged retinas showed enrichment for genes involved in the binding of integrins and fibronectin, as well as isomerase, peptidase, and chaperone function. (B) GO analysis of the molecular function of SASP factors in NMDA damaged retinas showed enrichment of genes responsible for lipase inhibitor activity, proteasome activation, and protein chaperone activity. SASP factors were included in the overrepresentation analysis if they had an adjusted p-value <0.05 and log₂FC > 1. GO terms were included in each heatmap if they were enriched for at least two time points. Gray cells indicate time points at which the respective term was not enriched.