FIGURE 2

FIGURE 2

Differentially expressed SASP factors after NMDA damage. Bulk RNAseq was performed on whole zebrafish retinas after intravitreal injections of NMDA and compared to undamaged controls. (A–C) Volcano plots showing differentially expressed SASP factors at the indicated times post damage. Dashed lines represent values with a |log₂FC| > 2 and p-values <10⁻⁶. Top significantly upregulated factors are labeled for each time point. (D) Heatmap showing enrichment of SASP factors at the indicated times post NMDA damage. SASP factors were included in the heatmap if they had a log₂FC > 3.5 with p-values <10⁻²⁰ for at least one time point; bolded genes are part of the SRRF.