ZFIN Image: Ye et al., 2025, Fig. 5

Image

Figure Caption

Fig. 5 TGF-β pathway inhibitor SB 431542 mitigates Klebsiella pneumoniae-induced lung injury in zebrafish. (A) TGF-β inhibitor SB 431542 significantly reduced neutrophil aggregation induced by K. pneumoniae infection. (B) The number of neutrophils in the SB 431542-treated group was significantly lower than in the infection group (p < 0.05, Student’s t-test). (C–D) The concentrations of IL-1β (C) and TNF-α (D) cytokines were significantly reduced following SB 431542 treatment (p < 0.05, Student’s t-test). (E–F) qRT-PCR validation showed that IL-1β (E) and TNF-α (F) gene expression levels were significantly downregulated in the SB 431542-treated group (p < 0.01, Student’s t-test).

Acknowledgments

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