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Fig. 1 A) Wildtype Cyp1b1 exon structure, substrate recognition sites (SRSs), and the cysteine ligand containing Cys loop are shown. Additionally, forward & reverse primer location, sgRNA target sites, and deletion positions against the WT coding sequence are shown. B) Mutant Cyp1b1 exon structure is shown. Additionally, forward & reverse primer location and frameshift mutation position proceeding the early stop codon against the mutant coding sequence are shown. The Cys loop containing the heme-binding cysteine ligand and SRS-6 are lost.
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