ZFIN Image: Siddiqui et al., 2024, Fig. 8.

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Figure Caption

Fig. 8.

Dual inhibition of NF-κB and Stat3 acts synergistically to suppress FynY531F-driven dopaminergic neuron degeneration. (A) Live confocal imaging of vDC eGFP dopaminergic neurons in 5 dpf control dat:eGFP and dat:eGFP;elav:Gal4; UAS:fynY531F larvae after treatment with mock DMSO, 5 µM S3I-201, 0.52 µM CAPE, and 5 µM S3I-201 plus 0.25 µM CAPE. (B) Quantification of vDC eGFP dopaminergic neuron number in 5 dpf control dat:eGFP and dat:eGFP;elav:Gal4; UAS:fynY531F larvae after treatment with mock DMSO, 5 µM S3I-201, 0.25 µM CAPE, and 5 µM S3I-201 plus 0.25 µM CAPE (n=12). Analysis was performed using two-way ANOVA with Tukey's multiple comparison. Bars represent mean±s.e.m. ****P<0.0001. Scale bars: 50 µm.

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