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Publication: Witkamp et al., 2024 - Lithium: effects in animal models of vanishing white matter are not promising
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Figure 2

Lithium improves motor deficits in mutant eif2b5^zc103/zc103 zebrafish. WT (circles) and eif2b5^zc103/zc103 (VWM; squares) zebrafish were treated with placebo (black; WT: n = 48, VWM: n = 38) or 1 mM lithium (blue; WT: n = 12, VWM: n = 26) and assessed on distance moved, moving time, and velocity at 7 dpf. The graphs show individual and mean values, +/− SEM. The shown motor behavior parameters differ significantly in placebo-treated WT versus placebo-treated eif2b5^zc103/zc103 zebrafish (p < 0.0001; not indicated, Supplementary Data Sheet S1). Treatment effects were statistically analyzed using an unpaired t-test or Mann–Whitney test (VWM, distance moved; Supplementary Data Sheet S1). *p < 0.05 and **p < 0.01.

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Phenotype details

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