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Figure 6
NAD+ and PAR metabolism is involved in AD pathogenesis. PARP1 hyperactivation in keratinocytes fueled by NAMPT-derived NAD+ exacerbates the inflammation and hyperplasia of AD. Consequently, pharmacological inhibition of NAMPT and PARP1 decreases disease-associated inflammation and proliferation, restoring skin homeostasis. Smartservier resources have been used to generate this figure.
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Full text @ Int. J. Mol. Sci.