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Figure 6

ID: ZDB-IMAGE-210327-31
Publication: Brown et al., 2021 - PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons
All Figures: Figures for Brown et al., 2021

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Figure 6

Reduced population of Otp⁺ progenitors in the TPp of pink1^-/- zebrafish at 3 months and 24 months of age. (A) Quantification of the number of Otp⁺Th1^- progenitors and the number of Otp⁺Th1⁺ DA neurons in the TPp at 3 months shows a significant reduction in the number of Otp⁺Th1^- progenitors in the pink1^-/- zebrafish compared to pink1^+/+ zebrafish (t-test, p = 0.0292, n = 2 fish for each), but no significant difference in the number of Otp⁺Th1⁺ DA neurons. (B) Quantification of the number of Otp⁺Th1^- progenitors and the number of Otp⁺Th1⁺ DA neurons in the TPp at 24 months shows a significant reduction in the number of Otp⁺Th1^- progenitors in the pink1^-/- zebrafish compared to pink1^+/+ zebrafish (t-test, p = 0.0259, n = 4 fish for each), and in the number of Otp⁺Th1⁺ DA neurons (t-test, p = 0.0453, n = 4 fish for each).

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